Abstract
Acetyl glyceryl ether phosphorylcholine (AGEPC) is a chemical that has the biological activity of what was formerly termed platelet-activating factor. We report here that synthetic AGEPC induces the contraction of guinea pig ileal smooth muscle. Antagonists of histamine, acetylcholine, and slow-reacting substances (SRS) do not block AGEPC-induced contraction. These responses were long lasting, resistant to washing, and displayed complete agonist specific desensitization. Histamine- and SRS-induced contractions were unaffected by AGEPC. These studies show that AGEPC has the potential to produce a component of anaphylactically induced smooth muscle contraction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 130-133 |
| Number of pages | 4 |
| Journal | American Journal of Physiology - Cell Physiology |
| Volume | 10 |
| Issue number | 2 |
| State | Published - 1981 |
| Externally published | Yes |
ASJC Scopus subject areas
- Physiology
- Cell Biology