Contraction of guinea pig ileal smooth muscle by acetyl glyceryl ether phosphorylcholine

S. R. Findlay, L. M. Lichtenstein, D. J. Hanahan, R. N. Pinckard

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

Acetyl glyceryl ether phosphorylcholine (AGEPC) is a chemical that has the biological activity of what was formerly termed platelet-activating factor. We report here that synthetic AGEPC induces the contraction of guinea pig ileal smooth muscle. Antagonists of histamine, acetylcholine, and slow-reacting substances (SRS) do not block AGEPC-induced contraction. These responses were long lasting, resistant to washing, and displayed complete agonist specific desensitization. Histamine- and SRS-induced contractions were unaffected by AGEPC. These studies show that AGEPC has the potential to produce a component of anaphylactically induced smooth muscle contraction.

Original languageEnglish (US)
Pages (from-to)130-133
Number of pages4
JournalAmerican Journal of Physiology - Cell Physiology
Volume10
Issue number2
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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