The glomerular mesangium is composed of matrix material and at least two cell types. One is a bone marrow-derived phagocyte and the other is a smooth muscle-like cell. The phagocytic cell represents approximately 3-7% of the total mesangial cell population. The other, more abundant, cell type appears to be contractile and therefore has been proposed to play a role in regulating the surface area for filtration, one component of the ultrafiltration coefficient, K[f]. In this review we discuss the contractile properties of cultured mesangial cells as well as the phenotypic alterations that lead to loss of isotonic contraction after prolonged culture.
|Original language||English (US)|
|Journal||American Journal of Physiology - Renal Fluid and Electrolyte Physiology|
|Publication status||Published - Jan 1 1985|
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