Abstract
Continuous-flow apneic ventilation (CFAV) by endobronchial insufflation of conditioned gas was evaluated in dogs during thoracotomy. In Group 1 (n = 6), dogs were anesthetized with pentobarbital (25 mg/kg). An endobronchial catheter (2.5 mm ID) was introduced into each mainstem bronchus using a fiberoptic bronchoscope and held in place by an endotracheal tube. Before the onset of CFAV (total flow 1.0 1 · kg-1 · min-1, the animals were paralyzed with pancuronium bromide and muscle relaxation was monitored with a peripheral nerve stimulator. The CFAV delivery system consisted of a flow meter, air/oxygen blender, oxygen analyzer, heated humidifier, and ultrasonic spirometer. Blood gas values were measured after 30 min of spontaneous ventilation, and CFAV with: 1) closed chest, fractional inspired O2 concentration (FI(O2)) 0.21; 2) open chest, FI(O2) 0.21; 3) open chest, FI(O2) 0.21, continuous positive airway pressure (CPAP) 5 mmHg; and 4) open chest FI(O2) 0.4, CPAP 5 mmHg. This last combination resulted in a mean Pa(O2) of 113.1 ± 5.5 (SEM) mmHg and a Pa(CO2) of 35.0 ± 2.1 (SEM) mmHg. In Group 2 (n = 6), animals with open chests were ventilated with CFAV (FI(O2) 0.4 and CPAP 5 mmHg) for 5 h. Adequate oxygenation and ventilation were achieved. Pa(CO2) after 5 h of CFAV was 41.8 ± 1.9 (SEM) mmHg compared with 40.8 ± 1.9 (SEM) mmHg during spontaneous breathing. Pa(O2) after 5 h of CFAV was 138.1 ± 11.7 (SEM) mmHg. There were no significant changes observed in vascular pressures. Significant differences in other hemodynamic parameters were probably due to pentobarbital anesthesia. Adequate gas exchange can be achieved during CFAV in dogs with open chests for 5 h.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 399-404 |
| Number of pages | 6 |
| Journal | Anesthesiology |
| Volume | 65 |
| Issue number | 4 |
| State | Published - 1986 |
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ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
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Continuous-flow apneic ventilation during thoracotomy. / Babinski, M. F.; Smith, R. B.; Bunegin, Leonid.
In: Anesthesiology, Vol. 65, No. 4, 1986, p. 399-404.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Continuous-flow apneic ventilation during thoracotomy
AU - Babinski, M. F.
AU - Smith, R. B.
AU - Bunegin, Leonid
PY - 1986
Y1 - 1986
N2 - Continuous-flow apneic ventilation (CFAV) by endobronchial insufflation of conditioned gas was evaluated in dogs during thoracotomy. In Group 1 (n = 6), dogs were anesthetized with pentobarbital (25 mg/kg). An endobronchial catheter (2.5 mm ID) was introduced into each mainstem bronchus using a fiberoptic bronchoscope and held in place by an endotracheal tube. Before the onset of CFAV (total flow 1.0 1 · kg-1 · min-1, the animals were paralyzed with pancuronium bromide and muscle relaxation was monitored with a peripheral nerve stimulator. The CFAV delivery system consisted of a flow meter, air/oxygen blender, oxygen analyzer, heated humidifier, and ultrasonic spirometer. Blood gas values were measured after 30 min of spontaneous ventilation, and CFAV with: 1) closed chest, fractional inspired O2 concentration (FI(O2)) 0.21; 2) open chest, FI(O2) 0.21; 3) open chest, FI(O2) 0.21, continuous positive airway pressure (CPAP) 5 mmHg; and 4) open chest FI(O2) 0.4, CPAP 5 mmHg. This last combination resulted in a mean Pa(O2) of 113.1 ± 5.5 (SEM) mmHg and a Pa(CO2) of 35.0 ± 2.1 (SEM) mmHg. In Group 2 (n = 6), animals with open chests were ventilated with CFAV (FI(O2) 0.4 and CPAP 5 mmHg) for 5 h. Adequate oxygenation and ventilation were achieved. Pa(CO2) after 5 h of CFAV was 41.8 ± 1.9 (SEM) mmHg compared with 40.8 ± 1.9 (SEM) mmHg during spontaneous breathing. Pa(O2) after 5 h of CFAV was 138.1 ± 11.7 (SEM) mmHg. There were no significant changes observed in vascular pressures. Significant differences in other hemodynamic parameters were probably due to pentobarbital anesthesia. Adequate gas exchange can be achieved during CFAV in dogs with open chests for 5 h.
AB - Continuous-flow apneic ventilation (CFAV) by endobronchial insufflation of conditioned gas was evaluated in dogs during thoracotomy. In Group 1 (n = 6), dogs were anesthetized with pentobarbital (25 mg/kg). An endobronchial catheter (2.5 mm ID) was introduced into each mainstem bronchus using a fiberoptic bronchoscope and held in place by an endotracheal tube. Before the onset of CFAV (total flow 1.0 1 · kg-1 · min-1, the animals were paralyzed with pancuronium bromide and muscle relaxation was monitored with a peripheral nerve stimulator. The CFAV delivery system consisted of a flow meter, air/oxygen blender, oxygen analyzer, heated humidifier, and ultrasonic spirometer. Blood gas values were measured after 30 min of spontaneous ventilation, and CFAV with: 1) closed chest, fractional inspired O2 concentration (FI(O2)) 0.21; 2) open chest, FI(O2) 0.21; 3) open chest, FI(O2) 0.21, continuous positive airway pressure (CPAP) 5 mmHg; and 4) open chest FI(O2) 0.4, CPAP 5 mmHg. This last combination resulted in a mean Pa(O2) of 113.1 ± 5.5 (SEM) mmHg and a Pa(CO2) of 35.0 ± 2.1 (SEM) mmHg. In Group 2 (n = 6), animals with open chests were ventilated with CFAV (FI(O2) 0.4 and CPAP 5 mmHg) for 5 h. Adequate oxygenation and ventilation were achieved. Pa(CO2) after 5 h of CFAV was 41.8 ± 1.9 (SEM) mmHg compared with 40.8 ± 1.9 (SEM) mmHg during spontaneous breathing. Pa(O2) after 5 h of CFAV was 138.1 ± 11.7 (SEM) mmHg. There were no significant changes observed in vascular pressures. Significant differences in other hemodynamic parameters were probably due to pentobarbital anesthesia. Adequate gas exchange can be achieved during CFAV in dogs with open chests for 5 h.
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M3 - Article
C2 - 3767038
AN - SCOPUS:0022545325
VL - 65
SP - 399
EP - 404
JO - Anesthesiology
JF - Anesthesiology
SN - 0003-3022
IS - 4
ER -