Contemporary Model-Free Methods for Linkage Analysis

Laura Almasy, John Blangero

    Research output: Chapter in Book/Report/Conference proceedingChapter

    14 Scopus citations


    Model-free linkage methods are based on identifying regions of the genome in which patterns of allele sharing among family members correspond to patterns of phenotype correlation among family members. Two general classes of model-free linkage methods are discussed in this chapter, relative pair methods designed primarily for analysis of discrete traits and variance component methods designed primarily for analysis of quantitative traits. These methods have been used to identify numerous genes influencing complex human phenotypes and remain viable approaches to gene localization in the twenty-first century.

    Original languageEnglish (US)
    Title of host publicationGenetic Dissection of Complex Traits
    EditorsD.C. Rao, Charles Gu
    Number of pages19
    StatePublished - 2008

    Publication series

    NameAdvances in Genetics
    ISSN (Print)0065-2660

    ASJC Scopus subject areas

    • Genetics


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