Contemporary Model-Free Methods for Linkage Analysis

Laura Almasy, John Blangero

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations


Model-free linkage methods are based on identifying regions of the genome in which patterns of allele sharing among family members correspond to patterns of phenotype correlation among family members. Two general classes of model-free linkage methods are discussed in this chapter, relative pair methods designed primarily for analysis of discrete traits and variance component methods designed primarily for analysis of quantitative traits. These methods have been used to identify numerous genes influencing complex human phenotypes and remain viable approaches to gene localization in the twenty-first century.

Original languageEnglish (US)
Title of host publicationGenetic Dissection of Complex Traits
EditorsD.C. Rao, Charles Gu
Number of pages19
StatePublished - 2008
Externally publishedYes

Publication series

NameAdvances in Genetics
ISSN (Print)0065-2660

ASJC Scopus subject areas

  • Genetics


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