Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13)

Melina Carapeti, Ricardo C.T. Aguiar, Ann E. Watmore, John M. Goldman, Nicholas C.P. Cross

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

We have recently cloned the inv(8)(p11q13) in a patient with acute myeloid leukemia (AML), and demonstrated a fusion between the MOZ and TIF2 genes at 8p11 and 8q13, respectively. We have partially characterized a further case of AML with the same karyotypic abnormality. Rearrangements were detected by Southern blotting with a TIF2 probe that was close to the breakpoint in the original inv(8) case and with a MOZ probe corresponding to the breakpoint cluster region in the t(8;16)(p11;p13). These findings indicate the existence of breakpoint cluster regions within both genes and demonstrate that the MOZ-TIF2 fusion is consistently associated with the inv(8)(p11q13). Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)70-72
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume113
Issue number1
DOIs
StatePublished - Aug 1999
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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