Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13)

Melina Carapeti; Ricardo C.T. Aguiar; Ann E. Watmore; John M. Goldman; Nicholas C.P. Cross

doi:10.1016/S0165-4608(99)00007-2

Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13)

Melina Carapeti, Ricardo C.T. Aguiar, Ann E. Watmore, John M. Goldman, Nicholas C.P. Cross

Research output: Contribution to journal › Article › peer-review

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Abstract

We have recently cloned the inv(8)(p11q13) in a patient with acute myeloid leukemia (AML), and demonstrated a fusion between the MOZ and TIF2 genes at 8p11 and 8q13, respectively. We have partially characterized a further case of AML with the same karyotypic abnormality. Rearrangements were detected by Southern blotting with a TIF2 probe that was close to the breakpoint in the original inv(8) case and with a MOZ probe corresponding to the breakpoint cluster region in the t(8;16)(p11;p13). These findings indicate the existence of breakpoint cluster regions within both genes and demonstrate that the MOZ-TIF2 fusion is consistently associated with the inv(8)(p11q13). Copyright (C) 1999 Elsevier Science Inc.

Original language	English (US)
Pages (from-to)	70-72
Number of pages	3
Journal	Cancer Genetics and Cytogenetics
Volume	113
Issue number	1
DOIs	https://doi.org/10.1016/S0165-4608(99)00007-2
State	Published - Aug 1999
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1016/S0165-4608(99)00007-2

Cite this

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title = "Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13)",

abstract = "We have recently cloned the inv(8)(p11q13) in a patient with acute myeloid leukemia (AML), and demonstrated a fusion between the MOZ and TIF2 genes at 8p11 and 8q13, respectively. We have partially characterized a further case of AML with the same karyotypic abnormality. Rearrangements were detected by Southern blotting with a TIF2 probe that was close to the breakpoint in the original inv(8) case and with a MOZ probe corresponding to the breakpoint cluster region in the t(8;16)(p11;p13). These findings indicate the existence of breakpoint cluster regions within both genes and demonstrate that the MOZ-TIF2 fusion is consistently associated with the inv(8)(p11q13). Copyright (C) 1999 Elsevier Science Inc.",

author = "Melina Carapeti and Aguiar, {Ricardo C.T.} and Watmore, {Ann E.} and Goldman, {John M.} and Cross, {Nicholas C.P.}",

note = "Funding Information: This work was supported by the Leukaemia Research Fund.",

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T1 - Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13)

AU - Carapeti, Melina

AU - Aguiar, Ricardo C.T.

AU - Watmore, Ann E.

AU - Goldman, John M.

AU - Cross, Nicholas C.P.

N1 - Funding Information: This work was supported by the Leukaemia Research Fund.

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Y1 - 1999/8

N2 - We have recently cloned the inv(8)(p11q13) in a patient with acute myeloid leukemia (AML), and demonstrated a fusion between the MOZ and TIF2 genes at 8p11 and 8q13, respectively. We have partially characterized a further case of AML with the same karyotypic abnormality. Rearrangements were detected by Southern blotting with a TIF2 probe that was close to the breakpoint in the original inv(8) case and with a MOZ probe corresponding to the breakpoint cluster region in the t(8;16)(p11;p13). These findings indicate the existence of breakpoint cluster regions within both genes and demonstrate that the MOZ-TIF2 fusion is consistently associated with the inv(8)(p11q13). Copyright (C) 1999 Elsevier Science Inc.

AB - We have recently cloned the inv(8)(p11q13) in a patient with acute myeloid leukemia (AML), and demonstrated a fusion between the MOZ and TIF2 genes at 8p11 and 8q13, respectively. We have partially characterized a further case of AML with the same karyotypic abnormality. Rearrangements were detected by Southern blotting with a TIF2 probe that was close to the breakpoint in the original inv(8) case and with a MOZ probe corresponding to the breakpoint cluster region in the t(8;16)(p11;p13). These findings indicate the existence of breakpoint cluster regions within both genes and demonstrate that the MOZ-TIF2 fusion is consistently associated with the inv(8)(p11q13). Copyright (C) 1999 Elsevier Science Inc.

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Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13)

Abstract

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