Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13)

Melina Carapeti, Ricardo C T Aguiar, Ann E. Watmore, John M. Goldman, Nicholas C P Cross

Research output: Contribution to journalArticle

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Abstract

We have recently cloned the inv(8)(p11q13) in a patient with acute myeloid leukemia (AML), and demonstrated a fusion between the MOZ and TIF2 genes at 8p11 and 8q13, respectively. We have partially characterized a further case of AML with the same karyotypic abnormality. Rearrangements were detected by Southern blotting with a TIF2 probe that was close to the breakpoint in the original inv(8) case and with a MOZ probe corresponding to the breakpoint cluster region in the t(8;16)(p11;p13). These findings indicate the existence of breakpoint cluster regions within both genes and demonstrate that the MOZ-TIF2 fusion is consistently associated with the inv(8)(p11q13). Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)70-72
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume113
Issue number1
DOIs
StatePublished - Aug 1999
Externally publishedYes

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Acute Myeloid Leukemia
Southern Blotting
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13). / Carapeti, Melina; Aguiar, Ricardo C T; Watmore, Ann E.; Goldman, John M.; Cross, Nicholas C P.

In: Cancer Genetics and Cytogenetics, Vol. 113, No. 1, 08.1999, p. 70-72.

Research output: Contribution to journalArticle

Carapeti, Melina ; Aguiar, Ricardo C T ; Watmore, Ann E. ; Goldman, John M. ; Cross, Nicholas C P. / Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13). In: Cancer Genetics and Cytogenetics. 1999 ; Vol. 113, No. 1. pp. 70-72.
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