TY - JOUR
T1 - Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13)
AU - Carapeti, Melina
AU - Aguiar, Ricardo C.T.
AU - Watmore, Ann E.
AU - Goldman, John M.
AU - Cross, Nicholas C.P.
N1 - Funding Information:
This work was supported by the Leukaemia Research Fund.
PY - 1999/8
Y1 - 1999/8
N2 - We have recently cloned the inv(8)(p11q13) in a patient with acute myeloid leukemia (AML), and demonstrated a fusion between the MOZ and TIF2 genes at 8p11 and 8q13, respectively. We have partially characterized a further case of AML with the same karyotypic abnormality. Rearrangements were detected by Southern blotting with a TIF2 probe that was close to the breakpoint in the original inv(8) case and with a MOZ probe corresponding to the breakpoint cluster region in the t(8;16)(p11;p13). These findings indicate the existence of breakpoint cluster regions within both genes and demonstrate that the MOZ-TIF2 fusion is consistently associated with the inv(8)(p11q13). Copyright (C) 1999 Elsevier Science Inc.
AB - We have recently cloned the inv(8)(p11q13) in a patient with acute myeloid leukemia (AML), and demonstrated a fusion between the MOZ and TIF2 genes at 8p11 and 8q13, respectively. We have partially characterized a further case of AML with the same karyotypic abnormality. Rearrangements were detected by Southern blotting with a TIF2 probe that was close to the breakpoint in the original inv(8) case and with a MOZ probe corresponding to the breakpoint cluster region in the t(8;16)(p11;p13). These findings indicate the existence of breakpoint cluster regions within both genes and demonstrate that the MOZ-TIF2 fusion is consistently associated with the inv(8)(p11q13). Copyright (C) 1999 Elsevier Science Inc.
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U2 - 10.1016/S0165-4608(99)00007-2
DO - 10.1016/S0165-4608(99)00007-2
M3 - Article
C2 - 10459350
AN - SCOPUS:0032817504
SN - 0165-4608
VL - 113
SP - 70
EP - 72
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -