TY - JOUR
T1 - Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function
T2 - Studies in adult mice hippocampus
AU - Deltheil, Thierry
AU - Guiard, Bruno P.
AU - Guilloux, Jean Philippe
AU - Nicolas, Lorelei
AU - Deloménie, Claudine
AU - Repérant, Christelle
AU - Maitre, Erwan Le
AU - Leroux-Nicollet, Isabelle
AU - Benmansour, Saloua
AU - Coudoré, François
AU - David, Denis J.
AU - Gardier, Alain M.
N1 - Funding Information:
During the performance of this work, B.P. G., J-P. G., T.D. and L.N. were recipients of a fellowship from the “Ministère de l'Enseignement Supérieur et de la Recherche”. In addition, B.P. G. was a recipient of a fellowship from “La Fondation pour la Recherche Médicale”. We are grateful to GlaxoSmithKline for the generous gifts of paroxetine.
PY - 2008/8
Y1 - 2008/8
N2 - In vivo intracerebral microdialysis is an important neurochemical technique that has been applied extensively in genetic and pharmacological studies aimed at investigating the relationship between neurotransmitters. Among the main interests of microdialysis application is the infusion of drugs through the microdialysis probe (reverse dialysis) in awake, freely moving animals. As an example of the relevance of intracerebral microdialysis, this review will focus on our recent neurochemical results showing the impact of Brain-Derived Neurotrophic Factor (BDNF) on serotonergic neurotransmission in basal and stimulated conditions. Indeed, although the elevation of 5-HT outflow induced by chronic administration of selective serotonin reuptake inhibitors (SSRIs) causes an increase in BDNF protein levels and expression (mRNA) in the hippocampus of rodents, the reciprocal interaction has not been demonstrated yet. Thus, the neurochemical sight of this question will be addressed here by examining the consequences of either a constitutive decrease or increase in brain BDNF protein levels on hippocampal extracellular levels of 5-HT in conscious mice.
AB - In vivo intracerebral microdialysis is an important neurochemical technique that has been applied extensively in genetic and pharmacological studies aimed at investigating the relationship between neurotransmitters. Among the main interests of microdialysis application is the infusion of drugs through the microdialysis probe (reverse dialysis) in awake, freely moving animals. As an example of the relevance of intracerebral microdialysis, this review will focus on our recent neurochemical results showing the impact of Brain-Derived Neurotrophic Factor (BDNF) on serotonergic neurotransmission in basal and stimulated conditions. Indeed, although the elevation of 5-HT outflow induced by chronic administration of selective serotonin reuptake inhibitors (SSRIs) causes an increase in BDNF protein levels and expression (mRNA) in the hippocampus of rodents, the reciprocal interaction has not been demonstrated yet. Thus, the neurochemical sight of this question will be addressed here by examining the consequences of either a constitutive decrease or increase in brain BDNF protein levels on hippocampal extracellular levels of 5-HT in conscious mice.
KW - Antidepressant drugs
KW - BDNF
KW - Conventional microdialysis
KW - Genetically modified animals
KW - Neurogenesis
KW - Serotonin
KW - Zero net flux method of quantitative microdialysis
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U2 - 10.1016/j.pbb.2007.09.018
DO - 10.1016/j.pbb.2007.09.018
M3 - Review article
C2 - 17980409
AN - SCOPUS:44849113474
SN - 0091-3057
VL - 90
SP - 174
EP - 183
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 2
ER -