Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: Studies in adult mice hippocampus

Thierry Deltheil, Bruno P. Guiard, Jean Philippe Guilloux, Lorelei Nicolas, Claudine Deloménie, Christelle Repérant, Erwan Le Maitre, Isabelle Leroux-Nicollet, Saloua Benmansour, François Coudoré, Denis J. David, Alain M. Gardier

Research output: Contribution to journalReview article

46 Scopus citations

Abstract

In vivo intracerebral microdialysis is an important neurochemical technique that has been applied extensively in genetic and pharmacological studies aimed at investigating the relationship between neurotransmitters. Among the main interests of microdialysis application is the infusion of drugs through the microdialysis probe (reverse dialysis) in awake, freely moving animals. As an example of the relevance of intracerebral microdialysis, this review will focus on our recent neurochemical results showing the impact of Brain-Derived Neurotrophic Factor (BDNF) on serotonergic neurotransmission in basal and stimulated conditions. Indeed, although the elevation of 5-HT outflow induced by chronic administration of selective serotonin reuptake inhibitors (SSRIs) causes an increase in BDNF protein levels and expression (mRNA) in the hippocampus of rodents, the reciprocal interaction has not been demonstrated yet. Thus, the neurochemical sight of this question will be addressed here by examining the consequences of either a constitutive decrease or increase in brain BDNF protein levels on hippocampal extracellular levels of 5-HT in conscious mice.

Original languageEnglish (US)
Pages (from-to)174-183
Number of pages10
JournalPharmacology Biochemistry and Behavior
Volume90
Issue number2
DOIs
StatePublished - Aug 1 2008

Keywords

  • Antidepressant drugs
  • BDNF
  • Conventional microdialysis
  • Genetically modified animals
  • Neurogenesis
  • Serotonin
  • Zero net flux method of quantitative microdialysis

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: Studies in adult mice hippocampus'. Together they form a unique fingerprint.

Cite this