Consenso expandido do BCTRIMS para o tratamento da esclerose múltipla. I. As evidências para o uso de imunossupressores, plasmaférese e transplante autólogo de células tronco

Translated title of the contribution: The BCTRIMS expanded consensus on treatment of multiple sclerosis. I. The evidences for the use of immunossupressive agents, plasma exchange and autologous hematopoietic stem cell transplantation

Dagoberto Callegaro, Marco Aurélio Lana-Peixoto, Marcos Aurélio Moreira, Paulo Eurípedes Marchiori, Luiz Alberto Bacheschi, Walter Oleschko Arruda, Gilberto Belisário Campos, Angelina Maria Martins Lino, Aílton Souza Melo, Fernando Coronetti Gomes da Rocha, Maria Lúcia Brito Ferreira, Luiz Ataíde, Damacio Ramón Kaiman Maciel, Alberto Alain Gabbai, Antônio Lúcio Teixeira, Ayrton Gomes Da Fonseca Filho, Bianca Etelvina Santos de Oliveira, Carla Vieira Stella, Carlos Alberto De Almeida Boer, Carlos Antônio Silveira PagliusoCarlos Otávio Brandão, Carolina Reis Araújo, Caroline Miranda Botelho, Clodoaldo Pirani, Denise Sisterolli Diniz, Elizabeth Regina Comini Frota, Elza Dias Tosta da Silva, Fernanda Bahadian Bardy, Francisco Di Biase, George Linard Silva Malveira, Igor Levy Reis, Jair Urbano da Silva, Luiz Carlos Coral, Márcio Antônio da Silva, Marcos Aurélio Peterlevitz, Maria Ângela Amaral Lorenti, Maria Fernanda Mendes, Maria Sheila Guimarães Rocha, Mauro Pedro Da Cunha, Norton Tadeu Goulart, Paulo Norberto Discher Sá, Paulo Virgolino Da Nóbrega, Renan Barros Domingues, Renata Parissi Buainain, Rogério De Rizo Morales, Rosana Ferreira de Rezende, Sebastião Eurico De Melo Souza, Sérgio Roberto Haussen, Sheila Bernardino Fenelon, Shirley Silva Lacerda, Sidney Gomes, Suzana Costa Nunes Machado, Tatiana De Oliveira Yokomizo, Vitor Geraldi Haase, Wagner De Góes Horta, Walter Roque Teixeira, Yara Dadalti Fragoso, Yuna Ribeiro de Araújo

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Since the sixties immunosuppressive agents have been used in the treatment of multiple sclerosis as there was cumulating evidence of the inflammatory nature of the disease. Cyclophosphamide, azathioprine and methotrexate have been the most frequently employed drugs whereas other agents such as cyclosporine and cladribine have been recently tested for RRMS. Mithoxantrone, on the other hand, was approved by the FDA for treatment of aggressive forms of the disease. Other immunointerventions such as plasma exchange and autologous hematopoietic stem cell transplantation have recently been employed in some special circumstances. This paper analyses the most important published data on the use of the immunosuppressive agents, plasma exchange and autologous hematopoietic stem cell transplantation according to the classes of evidences and types of recommendations of these drugs and immunointerventions. It provides sufficient information to support the guidelines expressed in the BCTRIMS Expanded Consensus on Treatment of MS.

Translated title of the contributionThe BCTRIMS expanded consensus on treatment of multiple sclerosis. I. The evidences for the use of immunossupressive agents, plasma exchange and autologous hematopoietic stem cell transplantation
Original languagePortuguese
Pages (from-to)869-874
Number of pages6
JournalArquivos de neuro-psiquiatria
Volume60
Issue number3 B
DOIs
StatePublished - Sep 2002
Externally publishedYes

Keywords

  • Autologous hematopoietic stem cell transplantation
  • Immunosuppressive agents
  • Multiple sclerosis
  • Plasma exchange
  • Treatment

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Biological Psychiatry

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