Connexin arrests the cell cycle through cytosolic retention of an E3 ligase

Qian Shi, Jean X. Jiang

Research output: Contribution to journalComment/debatepeer-review

5 Scopus citations

Abstract

The gap junction proteins connexins play important roles in cell growth and differentiation; however, the underlying mechanism remains largely elusive. We recently identified a channel-independent role of connexins in cell cycle control in which connexin 50 directly interacts with S-phase kinase 2 and prevents its nuclear localization, resulting in p27/p57 protection and cell cycle arrest.

Original languageEnglish (US)
Article numbere1132119
JournalMolecular and Cellular Oncology
Volume3
Issue number2
DOIs
StatePublished - Mar 3 2016

Keywords

  • Cell cycle
  • E3 ligase Skp2
  • connexin
  • lens cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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