Abstract
The gap junction proteins connexins play important roles in cell growth and differentiation; however, the underlying mechanism remains largely elusive. We recently identified a channel-independent role of connexins in cell cycle control in which connexin 50 directly interacts with S-phase kinase 2 and prevents its nuclear localization, resulting in p27/p57 protection and cell cycle arrest.
Original language | English (US) |
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Article number | e1132119 |
Journal | Molecular and Cellular Oncology |
Volume | 3 |
Issue number | 2 |
DOIs |
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State | Published - Mar 3 2016 |
Keywords
- Cell cycle
- E3 ligase Skp2
- connexin
- lens cells
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research