Connectivity of the subthalamic nucleus and globus pallidus pars interna to regions within the speech network: A meta-analytic connectivity study

Jordan L. Manes, Amy L. Parkinson, Charles R. Larson, Jeremy D. Greenlee, Simon B. Eickhoff, Daniel M. Corcos, Donald A. Robin

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Cortico-basal ganglia connections are involved in a range of behaviors within motor, cognitive, and emotional domains; however, the whole-brain functional connections of individual nuclei are poorly understood in humans. The first aim of this study was to characterize and compare the connectivity of the subthalamic nucleus (STN) and globus pallidus pars interna (GPi) using meta-analytic connectivity modeling. Structure-based activation likelihood estimation meta-analyses were performed for STN and GPi seeds using archived functional imaging coordinates from the BrainMap database. Both regions coactivated with caudate, putamen, thalamus, STN, GPi, and GPe, SMA, IFG, and insula. Contrast analyses also revealed coactivation differences within SMA, IFG, insula, and premotor cortex. The second aim of this study was to examine the degree of overlap between the connectivity maps derived for STN and GPi and a functional activation map representing the speech network. To do this, we examined the intersection of coactivation maps and their respective contrasts (STN>GPi and GPi>STN) with a coordinate-based meta-analysis of speech function. In conjunction with the speech map, both STN and GPi coactivation maps revealed overlap in the anterior insula with GPi map additionally showing overlap in the supplementary motor area (SMA). Among cortical regions activated by speech tasks, STN was found to have stronger connectivity than GPi with regions involved in cognitive linguistic processes (pre-SMA, dorsal anterior insula, and inferior frontal gyrus), while GPi demonstrated stronger connectivity to regions involved in motor speech processes (middle insula, SMA, and premotor cortex). Hum Brain Mapp 35:3499-3516, 2014.

Original languageEnglish (US)
Pages (from-to)3499-3516
Number of pages18
JournalHuman Brain Mapping
Volume35
Issue number7
DOIs
StatePublished - Jul 2014

Keywords

  • Connectivity
  • Globus pallidus
  • Meta-analysis
  • Motor speech
  • Speech cognition
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

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    Manes, J. L., Parkinson, A. L., Larson, C. R., Greenlee, J. D., Eickhoff, S. B., Corcos, D. M., & Robin, D. A. (2014). Connectivity of the subthalamic nucleus and globus pallidus pars interna to regions within the speech network: A meta-analytic connectivity study. Human Brain Mapping, 35(7), 3499-3516. https://doi.org/10.1002/hbm.22417