Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemia

Olga Sala-Torra, Holly M. Gundacker, Derek L. Stirewalt, Paula A. Ladne, Era L. Pogosova-Agadjanyan, Marilyn L. Slovak, Cheryl L. Willman, Shelly Heimfeld, David H. Boldt, Jerald P. Radich

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

We compared the gene expression profile of adult acute lymphoblastic leukemia (ALL) to normal hematopoietic and non-ALL samples using oligonucleotide arrays. Connective tissue growth factor (CTGF) was the highest overexpressed gene in B-cell ALL compared with the other groups, and displayed heterogeneous expression, suggesting it might have prognostic relevance. CTGF expression was examined by quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) on 79 adult ALL specimens. CTGF expression levels were significantly increased in ALL cases with B-lineage (P < .001), unfavorable cytogenetics (P < .001), and blasts expressing CD34 (P < .001). In a multivariate proportional hazards model, higher CTGF expression levels corresponded to worsening of overall survival (OS; hazard ratio 1.36, for each 10-fold increase in expression; P = .019). Further studies are ongoing to confirm the prognostic value of CTGF expression in ALL and to investigate its role in normal and abnormal lymphocyte biology.

Original languageEnglish (US)
Pages (from-to)3080-3083
Number of pages4
JournalBlood
Volume109
Issue number7
DOIs
StatePublished - Apr 1 2007

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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