Conjugated linoleic acid protects against age-associated bone loss in C57BL/6 female mice

Md Mizanur Rahman, Arunabh Bhattacharya, Jameela Banu, Gabriel Fernandes

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Osteoporosis is one of the major causes of morbidity in the elderly. Inflammation exerts a significant influence on bone turnover, inducing the chronic form of osteoporosis. Dietary nutrition has the capacity to modulate inflammatory response. Therefore, nutritional strategies and lifestyle changes may prevent age-related osteoporosis, thereby improving the quality of life of the elderly population. Conjugated linoleic acid (CLA) has been shown to positively influence calcium and bone metabolism. Hence, this study was undertaken to examine the effect of CLA on bone mineral density (BMD) in middle-aged C57BL/6 female mice. After 10 weeks on diet, CLA-fed mice (14 months) maintained a higher BMD in different bone regions than corn oil (CO)-fed mice. The increased BMD was accompanied by a decreased activity of proinflammatory cytokines (such as tumor necrosis factor α, interleukin-6 and the receptor activator of NF-κB ligand) and decreased osteoclast function. Furthermore, a significant decrease in fat mass and an increase in muscle mass were also observed in CLA-fed mice compared to CO-fed mice. In conclusion, these findings suggest that CLA may prevent the loss of bone and muscle mass by modulating markers of inflammation and osteoclastogenic factors.

Original languageEnglish (US)
Pages (from-to)467-474
Number of pages8
JournalJournal of Nutritional Biochemistry
Issue number7
StatePublished - Jul 2007


  • Aging
  • Bone
  • Conjugated linoleic acid
  • Cytokines
  • Inflammation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry


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