Congenital bronchiolo-alveolar airway malformation in a cynomolgus macaque (Macaca fascicularis)

Bridget S. Lewis, G. B. Hubbard, M. G. Mense, P. A. Frost

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Pulmonary congenital anomalies in animals are rare. Previously reported malformations include accessory lung formation, pulmonary hypoplasia, pulmonary agenesis, and various forms of hamartoma. Congenital bronchiolo-alveolar airway malformation, a new entity, is described in a 1-day-old male cynomolgus macaque. This neonate experienced breathing difficulties shortly after birth and died while therapy was being administered. Grossly, the right lung was markedly increased in size, firm, and pink. Histopathologically, sections of right lung showed irregular bronchiole-like and alveolus-like structures. There was marked widening of alveolar septae by loosely arranged mesenchymal cells and many centrally located capillaries. Alveoli were lined by cuboidal epithelial cells. There were scattered islands of immature cartilage. A grossly enlarged lung containing bronchiole-like and alveolus-like structures, immature cartilage islands, and many capillaries within alveolar septae on histopathologic examination, is inconsistent with previously described congenital pulmonary anomalies in animals and humans.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalJournal of medical primatology
Issue number1
StatePublished - Feb 2005
Externally publishedYes


  • Lung
  • Neonate
  • Primate

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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