Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry

Michael B. Mattammal; Hyung D. Chung; Randy Strong; Fong Fu Hsu

doi:10.1016/0378-4347(93)80310-Z

Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry

Michael B. Mattammal
, Hyung D. Chung
, Randy Strong
, Fong Fu Hsu

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Gas chromatography-mass spectrometry was used to identify a dopamine metabolite isolated from the substantia nigra of parkinsonian brain tissue. Incubation of dopamine with monoamine oxidase B gave the same product which was identified as 3,4-dihydroxyphenylacetaldehyde. The structure of the compound was established by chemical synthesis, metastable ion measurement and high-resolution mass spectrometry.

Original language	English (US)
Pages (from-to)	205-212
Number of pages	8
Journal	Journal of Chromatography B: Biomedical Sciences and Applications
Volume	614
Issue number	2
DOIs	https://doi.org/10.1016/0378-4347(93)80310-Z
State	Published - May 5 1993
Externally published	Yes

ASJC Scopus subject areas

General Chemistry

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10.1016/0378-4347(93)80310-Z

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title = "Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry",

abstract = "Gas chromatography-mass spectrometry was used to identify a dopamine metabolite isolated from the substantia nigra of parkinsonian brain tissue. Incubation of dopamine with monoamine oxidase B gave the same product which was identified as 3,4-dihydroxyphenylacetaldehyde. The structure of the compound was established by chemical synthesis, metastable ion measurement and high-resolution mass spectrometry.",

author = "Mattammal, \{Michael B.\} and Chung, \{Hyung D.\} and Randy Strong and Hsu, \{Fong Fu\}",

note = "Funding Information: This work was supported by the Department of Veterans Affairs. Mass spectraw ere obtained at the Center of Mass Spectrometry Resource, Washington University School of Medicine which is supported by NIH Grants RR-00954 and AM-20579.",

year = "1993",

month = may,

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doi = "10.1016/0378-4347(93)80310-Z",

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T1 - Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry

AU - Mattammal, Michael B.

AU - Chung, Hyung D.

AU - Strong, Randy

AU - Hsu, Fong Fu

N1 - Funding Information: This work was supported by the Department of Veterans Affairs. Mass spectraw ere obtained at the Center of Mass Spectrometry Resource, Washington University School of Medicine which is supported by NIH Grants RR-00954 and AM-20579.

PY - 1993/5/5

Y1 - 1993/5/5

N2 - Gas chromatography-mass spectrometry was used to identify a dopamine metabolite isolated from the substantia nigra of parkinsonian brain tissue. Incubation of dopamine with monoamine oxidase B gave the same product which was identified as 3,4-dihydroxyphenylacetaldehyde. The structure of the compound was established by chemical synthesis, metastable ion measurement and high-resolution mass spectrometry.

AB - Gas chromatography-mass spectrometry was used to identify a dopamine metabolite isolated from the substantia nigra of parkinsonian brain tissue. Incubation of dopamine with monoamine oxidase B gave the same product which was identified as 3,4-dihydroxyphenylacetaldehyde. The structure of the compound was established by chemical synthesis, metastable ion measurement and high-resolution mass spectrometry.

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DO - 10.1016/0378-4347(93)80310-Z

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ER -

Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry

Abstract

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