Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry

Michael B. Mattammal, Hyung D. Chung, Randy Strong, Fong Fu Hsu

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Abstract

Gas chromatography-mass spectrometry was used to identify a dopamine metabolite isolated from the substantia nigra of parkinsonian brain tissue. Incubation of dopamine with monoamine oxidase B gave the same product which was identified as 3,4-dihydroxyphenylacetaldehyde. The structure of the compound was established by chemical synthesis, metastable ion measurement and high-resolution mass spectrometry.

Original languageEnglish (US)
Pages (from-to)205-212
Number of pages8
JournalJournal of Chromatography B: Biomedical Sciences and Applications
Volume614
Issue number2
DOIs
StatePublished - May 5 1993
Externally publishedYes

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ASJC Scopus subject areas

  • Chemistry(all)

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