@inproceedings{bfea327ede214451bbcd1b55d01e5015,
title = "Conductivity affects nanosecond electrical pulse induced pressure transient formation",
abstract = "Nanoporation occurs in cells exposed to high amplitude short duration (< 1μs) electrical pulses. The biophysical mechanism(s) responsible for nanoporation is unknown although several theories exist. Current theories focus exclusively on the electrical field, citing electrostriction, water dipole alignment and/or electrodeformation as the primary mechanisms for pore formation. Our group has shown that mechanical forces of substantial magnitude are also generated during nsEP exposures. We hypothesize that these mechanical forces may contribute to pore formation. In this paper, we report that alteration of the conductivity of the exposure solution also altered the level of mechanical forces generated during a nsEP exposure. By reducing the conductivity of the exposure solutions, we found that we could completely eliminate any pressure transients normally created by nsEP exposure. The data collected for this proceeding does not definitively show that the pressure transients previously identified contribute to nanoporation; however; it indicates that conductivity influences both survival and pressure transient formation.",
keywords = "conductivity, electrodeformation, mechanical stress, nanoporation, nanosecond electrical pulse",
author = "Roth, {Caleb C.} and Barnes, {Ronald A.} and Ibey, {Bennett L.} and Beier, {Hope T.} and Glickman, {Randolph D.}",
note = "Publisher Copyright: {\textcopyright} 2016 SPIE. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.; Optical Interactions with Tissue and Cells XXVII ; Conference date: 14-02-2016 Through 17-02-2016",
year = "2016",
doi = "10.1117/12.2214896",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Jansen, {E. Duco}",
booktitle = "Optical Interactions with Tissue and Cells XXVII",
}