Conducting clinical research with prescription opioid dependence: Defining the population

Roger D. Weiss, Jennifer S. Potter, Marc L. Copersino, Kristi Prather, Petra Jacobs, Scott Provost, David Chim, Jeffrey Selzer, Walter Ling

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Most treatment studies of opioid-dependent populations have focused predominantly on heroin users, despite a recent increase in those dependent upon prescription opioids. A key methodological challenge involved in studying the latter group involves defining the population. Specifically, researchers must decide whether to include (1) concurrent heroin users and (2) individuals with pain. The multi-site Prescription Opioid Addiction Treatment Study is examining treatments for this population. This paper describes various inclusion criteria considered by the study team related to heroin use and pain. The goal was to recruit a distinct but generalizable population of individuals dependent upon prescription opioids.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalAmerican Journal on Addictions
Issue number2
StatePublished - Mar 2010

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health


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