Concordance between the CC chemokine receptor 5 genetic determinants that alter risks of transmission and disease progression in children exposed perinatally to human immunodeficiency virus

Andrea Mangano, Enrique Gonzalez, Rahul Dhanda, Gabriel Catano, Mike Bamshad, Amanda Bock, Ravindranath Duggirala, Ken Williams, Srinivas Mummidi, Robert A. Clark, Seema S. Ahuja, Matthew J. Dolan, Rosa Bologna, Luisa Sen, Sunil K. Ahuja

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

If CC chemokine receptor 5 (CCR5)-dependent mechanisms at the time of initial virus exposure are important determinants of virus entry and disease outcome, then the polymorphisms in CCR5 that influence risk of transmission and disease progression should be similar; this hypothesis was tested in a cohort of 649 Argentinean children exposed perinatally to human immunodeficiency virus type 1 (HIV-1). Two lines of evidence support this hypothesis. First, CCR5 haplotype pairs associated with enhanced risk of transmission were the chief predictors of a faster disease course. Second, some of the haplotype pairs associated with altered rates of transmission and disease progression in children were similar to those that we previously found influenced outcome in European American adults. This concordance suggests that CCR5 haplotypes may serve as genetic rheostats that influence events occurring shortly after initial virus exposure, dictating not only virus entry but, by extension, also the extent of early viral replication.

Original languageEnglish (US)
Pages (from-to)1574-1585
Number of pages12
JournalJournal of Infectious Diseases
Volume183
Issue number11
DOIs
StatePublished - Jun 1 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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