Concordance between subjective and objective memory impairment in volunteer subjects

Montserrat Alegret; Octavio Rodríguez; Ana Espinosa; Gemma Ortega; Angela Sanabria; Sergi Valero; Isabel Hernández; Maitée Rosende-Roca; Liliana Vargas; Carla Abdelnour; Ana Mauleón; Anna Gailhajanet; Elvira Martín; Lluís Tárraga; Dorene M. Rentz; Rebecca E. Amariglio; Agustín Ruíz; Mercè Boada

doi:10.3233/JAD-150594

Concordance between subjective and objective memory impairment in volunteer subjects

Montserrat Alegret, Octavio Rodríguez, Ana Espinosa, Gemma Ortega, Angela Sanabria, Sergi Valero, Isabel Hernández, Maitée Rosende-Roca, Liliana Vargas, Carla Abdelnour, Ana Mauleón, Anna Gailhajanet, Elvira Martín, Lluís Tárraga, Dorene M. Rentz, Rebecca E. Amariglio, Agustín Ruíz, Mercè Boada

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

BACKGROUND: Subjective memory impairment (SMI) refers to subjective awareness of initial memory decline undetectable with existing standardized cognitive tests. The Face Name Associative Memory Exam (FNAME) was created to detect memory deficits in individuals with preclinical Alzheimer's disease (AD). We reported normative data of a Spanish version of FNAME (S-FNAME) in cognitively normal (CN) Spanish-speaking subjects >49. OBJECTIVE: To determine whether higher SMI [a modification of Memory Failures Everyday (MFE-30)] was related to worse memory performance (S-FNAME) or associated with greater affective symptoms in subjects >49; and whether MFE-30 and FNAME were able to discriminate between CN and mild cognitive impairment (MCI) subjects. METHODS: 317 subjects (CN = 196, MCI = 121) were included in the analysis because they attended the annual "Open House Initiative" at Memory Clinic Fundació ACE, were >49 years, literate, received S-FNAME, MFE-30, and Hospital Anxiety and Depression Scale, had Mini-Mental State Examination scores ≥27, and returned to complete a comprehensive diagnostic assessment. RESULTS: MFE-30 scores were associated with affective symptoms but not with S-FNAME performance. S-FNAME scores were related to performance on memory variables of NBACE (neuropsychological battery used in Fundació ACE). Although the MCI group showed significantly higher MFE-30 and worse S-FNAME scores than the CN group, their discriminability values were similar (Sensitivity: 49.6 versus 52.9; Specificity: 85.1 versus 83.6, respectively). CONCLUSIONS: SMI was more related to depressive symptoms than to S-FNAME memory performance; and S-FNAME scores were related to other episodic memory test performances, but neither to affective symptoms nor to SMI. MFE-30 and S-FNAME are not optimal for discriminating between CN and MCI groups. Longitudinal follow-up will determine if lower S-FNAME and higher SMI are related to increased risk of AD.

Original language	English (US)
Pages (from-to)	1109-1117
Number of pages	9
Journal	Journal of Alzheimer's Disease
Volume	48
Issue number	4
DOIs	https://doi.org/10.3233/JAD-150594
State	Published - Oct 27 2015
Externally published	Yes

Keywords

Episodic memory
FNAME
neuropsychology
preclinical Alzheimer's disease
subjective memory impairment

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.3233/JAD-150594

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Alegret, M., Rodríguez, O., Espinosa, A., Ortega, G., Sanabria, A., Valero, S., Hernández, I., Rosende-Roca, M., Vargas, L., Abdelnour, C., Mauleón, A., Gailhajanet, A., Martín, E., Tárraga, L., Rentz, D. M., Amariglio, R. E., Ruíz, A., & Boada, M. (2015). Concordance between subjective and objective memory impairment in volunteer subjects. Journal of Alzheimer's Disease, 48(4), 1109-1117. https://doi.org/10.3233/JAD-150594

Alegret, M, Rodríguez, O, Espinosa, A, Ortega, G, Sanabria, A, Valero, S, Hernández, I, Rosende-Roca, M, Vargas, L, Abdelnour, C, Mauleón, A, Gailhajanet, A, Martín, E, Tárraga, L, Rentz, DM, Amariglio, RE, Ruíz, A & Boada, M 2015, 'Concordance between subjective and objective memory impairment in volunteer subjects', Journal of Alzheimer's Disease, vol. 48, no. 4, pp. 1109-1117. https://doi.org/10.3233/JAD-150594

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title = "Concordance between subjective and objective memory impairment in volunteer subjects",

abstract = "BACKGROUND: Subjective memory impairment (SMI) refers to subjective awareness of initial memory decline undetectable with existing standardized cognitive tests. The Face Name Associative Memory Exam (FNAME) was created to detect memory deficits in individuals with preclinical Alzheimer's disease (AD). We reported normative data of a Spanish version of FNAME (S-FNAME) in cognitively normal (CN) Spanish-speaking subjects >49. OBJECTIVE: To determine whether higher SMI [a modification of Memory Failures Everyday (MFE-30)] was related to worse memory performance (S-FNAME) or associated with greater affective symptoms in subjects >49; and whether MFE-30 and FNAME were able to discriminate between CN and mild cognitive impairment (MCI) subjects. METHODS: 317 subjects (CN = 196, MCI = 121) were included in the analysis because they attended the annual {"}Open House Initiative{"} at Memory Clinic Fundaci{\'o} ACE, were >49 years, literate, received S-FNAME, MFE-30, and Hospital Anxiety and Depression Scale, had Mini-Mental State Examination scores ≥27, and returned to complete a comprehensive diagnostic assessment. RESULTS: MFE-30 scores were associated with affective symptoms but not with S-FNAME performance. S-FNAME scores were related to performance on memory variables of NBACE (neuropsychological battery used in Fundaci{\'o} ACE). Although the MCI group showed significantly higher MFE-30 and worse S-FNAME scores than the CN group, their discriminability values were similar (Sensitivity: 49.6 versus 52.9; Specificity: 85.1 versus 83.6, respectively). CONCLUSIONS: SMI was more related to depressive symptoms than to S-FNAME memory performance; and S-FNAME scores were related to other episodic memory test performances, but neither to affective symptoms nor to SMI. MFE-30 and S-FNAME are not optimal for discriminating between CN and MCI groups. Longitudinal follow-up will determine if lower S-FNAME and higher SMI are related to increased risk of AD.",

keywords = "Episodic memory, FNAME, neuropsychology, preclinical Alzheimer's disease, subjective memory impairment",

author = "Montserrat Alegret and Octavio Rodr{\'i}guez and Ana Espinosa and Gemma Ortega and Angela Sanabria and Sergi Valero and Isabel Hern{\'a}ndez and Mait{\'e}e Rosende-Roca and Liliana Vargas and Carla Abdelnour and Ana Maule{\'o}n and Anna Gailhajanet and Elvira Mart{\'i}n and Llu{\'i}s T{\'a}rraga and Rentz, {Dorene M.} and Amariglio, {Rebecca E.} and Agust{\'i}n Ru{\'i}z and Merc{\`e} Boada",

note = "Publisher Copyright: {\textcopyright} 2015 - IOS Press and the authors.",

year = "2015",

month = oct,

day = "27",

doi = "10.3233/JAD-150594",

language = "English (US)",

volume = "48",

pages = "1109--1117",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

publisher = "SAGE Publications Ltd",

number = "4",

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TY - JOUR

T1 - Concordance between subjective and objective memory impairment in volunteer subjects

AU - Alegret, Montserrat

AU - Rodríguez, Octavio

AU - Espinosa, Ana

AU - Ortega, Gemma

AU - Sanabria, Angela

AU - Valero, Sergi

AU - Hernández, Isabel

AU - Rosende-Roca, Maitée

AU - Vargas, Liliana

AU - Abdelnour, Carla

AU - Mauleón, Ana

AU - Gailhajanet, Anna

AU - Martín, Elvira

AU - Tárraga, Lluís

AU - Rentz, Dorene M.

AU - Amariglio, Rebecca E.

AU - Ruíz, Agustín

AU - Boada, Mercè

PY - 2015/10/27

Y1 - 2015/10/27

N2 - BACKGROUND: Subjective memory impairment (SMI) refers to subjective awareness of initial memory decline undetectable with existing standardized cognitive tests. The Face Name Associative Memory Exam (FNAME) was created to detect memory deficits in individuals with preclinical Alzheimer's disease (AD). We reported normative data of a Spanish version of FNAME (S-FNAME) in cognitively normal (CN) Spanish-speaking subjects >49. OBJECTIVE: To determine whether higher SMI [a modification of Memory Failures Everyday (MFE-30)] was related to worse memory performance (S-FNAME) or associated with greater affective symptoms in subjects >49; and whether MFE-30 and FNAME were able to discriminate between CN and mild cognitive impairment (MCI) subjects. METHODS: 317 subjects (CN = 196, MCI = 121) were included in the analysis because they attended the annual "Open House Initiative" at Memory Clinic Fundació ACE, were >49 years, literate, received S-FNAME, MFE-30, and Hospital Anxiety and Depression Scale, had Mini-Mental State Examination scores ≥27, and returned to complete a comprehensive diagnostic assessment. RESULTS: MFE-30 scores were associated with affective symptoms but not with S-FNAME performance. S-FNAME scores were related to performance on memory variables of NBACE (neuropsychological battery used in Fundació ACE). Although the MCI group showed significantly higher MFE-30 and worse S-FNAME scores than the CN group, their discriminability values were similar (Sensitivity: 49.6 versus 52.9; Specificity: 85.1 versus 83.6, respectively). CONCLUSIONS: SMI was more related to depressive symptoms than to S-FNAME memory performance; and S-FNAME scores were related to other episodic memory test performances, but neither to affective symptoms nor to SMI. MFE-30 and S-FNAME are not optimal for discriminating between CN and MCI groups. Longitudinal follow-up will determine if lower S-FNAME and higher SMI are related to increased risk of AD.

AB - BACKGROUND: Subjective memory impairment (SMI) refers to subjective awareness of initial memory decline undetectable with existing standardized cognitive tests. The Face Name Associative Memory Exam (FNAME) was created to detect memory deficits in individuals with preclinical Alzheimer's disease (AD). We reported normative data of a Spanish version of FNAME (S-FNAME) in cognitively normal (CN) Spanish-speaking subjects >49. OBJECTIVE: To determine whether higher SMI [a modification of Memory Failures Everyday (MFE-30)] was related to worse memory performance (S-FNAME) or associated with greater affective symptoms in subjects >49; and whether MFE-30 and FNAME were able to discriminate between CN and mild cognitive impairment (MCI) subjects. METHODS: 317 subjects (CN = 196, MCI = 121) were included in the analysis because they attended the annual "Open House Initiative" at Memory Clinic Fundació ACE, were >49 years, literate, received S-FNAME, MFE-30, and Hospital Anxiety and Depression Scale, had Mini-Mental State Examination scores ≥27, and returned to complete a comprehensive diagnostic assessment. RESULTS: MFE-30 scores were associated with affective symptoms but not with S-FNAME performance. S-FNAME scores were related to performance on memory variables of NBACE (neuropsychological battery used in Fundació ACE). Although the MCI group showed significantly higher MFE-30 and worse S-FNAME scores than the CN group, their discriminability values were similar (Sensitivity: 49.6 versus 52.9; Specificity: 85.1 versus 83.6, respectively). CONCLUSIONS: SMI was more related to depressive symptoms than to S-FNAME memory performance; and S-FNAME scores were related to other episodic memory test performances, but neither to affective symptoms nor to SMI. MFE-30 and S-FNAME are not optimal for discriminating between CN and MCI groups. Longitudinal follow-up will determine if lower S-FNAME and higher SMI are related to increased risk of AD.

KW - Episodic memory

KW - FNAME

KW - neuropsychology

KW - preclinical Alzheimer's disease

KW - subjective memory impairment

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Concordance between subjective and objective memory impairment in volunteer subjects

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ASJC Scopus subject areas

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