Levels of antibodies against infectious canine hepatitis virus (ICHV) and Bacillus Calmette-Guérin cell wall (BCG-CW) antigens in sera from BCG-CW inoculated dams, uninoculated dams, neonate pups in litters born to these dams and normal female dogs were measured by solid phase bead-type radioimmunoassay (SBRIA) tests. Significantly higher levels of antibodies reactive with BCG-CW, but not ICHV, antigens were found in the sera from two day old pups born to BCG-CW inoculated, ICHV-immune dams than in sera from two day old pups born to ICHV-immune dams not inoculated with BCG-CW. These results demonstrate that maternal antibodies against antigens of a non-viable immunotherapeutically active preparation (BCG-CW), and against antigens of ICHV, a canine virus routinely used in vaccines, can be passively transferred from dams to newborn pups.
ASJC Scopus subject areas
- Developmental Biology