Concanavalin-A stimulates human chorionic gonadotrop in (hCG) and hCG-alpha secretion by human choriocarcinoma cells

Robert Benveniste, K. V. Speeg, Allen Long, David Rabinowitz

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The plant lectin Concanavalin-A stimulates the secretion of human chorionic gonadotropin and free alpha subunit by cultured human choriocarcinoma cells in a dose dependent and time dependent manner. This stimulation is prevented by alpha-methyl-D-mannopyranoside, a Concanavalin-A specific hapten sugar. This is the first report of a lectin stimulating the secretion of a glycoprotein hormone. Since the stimulation likely occurs subsequent to interactions at the membrane level, Concanavalin-A may represent a probe for studying membrane-related events involved in the control of human chorionic gonadotropin secretion.

Original languageEnglish (US)
Pages (from-to)1082-1087
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume84
Issue number4
DOIs
StatePublished - Oct 30 1978
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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