The plant lectin Concanavalin-A stimulates the secretion of human chorionic gonadotropin and free alpha subunit by cultured human choriocarcinoma cells in a dose dependent and time dependent manner. This stimulation is prevented by alpha-methyl-D-mannopyranoside, a Concanavalin-A specific hapten sugar. This is the first report of a lectin stimulating the secretion of a glycoprotein hormone. Since the stimulation likely occurs subsequent to interactions at the membrane level, Concanavalin-A may represent a probe for studying membrane-related events involved in the control of human chorionic gonadotropin secretion.
|Original language||English (US)|
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Oct 30 1978|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology