Concanavalin-A stimulates human chorionic gonadotrop in (hCG) and hCG-alpha secretion by human choriocarcinoma cells

Robert Benveniste; K. V. Speeg; Allen Long; David Rabinowitz

doi:10.1016/0006-291X(78)91694-7

Concanavalin-A stimulates human chorionic gonadotrop in (hCG) and hCG-alpha secretion by human choriocarcinoma cells

Robert Benveniste, K. V. Speeg, Allen Long, David Rabinowitz

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The plant lectin Concanavalin-A stimulates the secretion of human chorionic gonadotropin and free alpha subunit by cultured human choriocarcinoma cells in a dose dependent and time dependent manner. This stimulation is prevented by alpha-methyl-D-mannopyranoside, a Concanavalin-A specific hapten sugar. This is the first report of a lectin stimulating the secretion of a glycoprotein hormone. Since the stimulation likely occurs subsequent to interactions at the membrane level, Concanavalin-A may represent a probe for studying membrane-related events involved in the control of human chorionic gonadotropin secretion.

Original language	English (US)
Pages (from-to)	1082-1087
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	84
Issue number	4
DOIs	https://doi.org/10.1016/0006-291X(78)91694-7
State	Published - Oct 30 1978
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Concanavalin-A stimulates human chorionic gonadotrop in (hCG) and hCG-alpha secretion by human choriocarcinoma cells",

abstract = "The plant lectin Concanavalin-A stimulates the secretion of human chorionic gonadotropin and free alpha subunit by cultured human choriocarcinoma cells in a dose dependent and time dependent manner. This stimulation is prevented by alpha-methyl-D-mannopyranoside, a Concanavalin-A specific hapten sugar. This is the first report of a lectin stimulating the secretion of a glycoprotein hormone. Since the stimulation likely occurs subsequent to interactions at the membrane level, Concanavalin-A may represent a probe for studying membrane-related events involved in the control of human chorionic gonadotropin secretion.",

author = "Robert Benveniste and Speeg, {K. V.} and Allen Long and David Rabinowitz",

note = "Funding Information: *This work was supported by grants from the National Institutes l-ROl-HO-10128-01 and 2-P30-HD-05797-07 and the American Cancer",

year = "1978",

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T1 - Concanavalin-A stimulates human chorionic gonadotrop in (hCG) and hCG-alpha secretion by human choriocarcinoma cells

AU - Benveniste, Robert

AU - Speeg, K. V.

AU - Long, Allen

AU - Rabinowitz, David

N1 - Funding Information: *This work was supported by grants from the National Institutes l-ROl-HO-10128-01 and 2-P30-HD-05797-07 and the American Cancer

PY - 1978/10/30

Y1 - 1978/10/30

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