Computer simulation of the movement of lithium across erythrocyte membranes in vitro

Jack W. London, David Burns, Alan Frazer, David Brunswick, David Garfinkel, Joe Mendel

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Computer simulation of data obtained from in vitro lithium uptake experiments was used to define influx and efflux components of the net flux of lithium transport across erythrocyte membranes. The variation in in vitro erythrocyte to medium lithium distribution ratios for different individuals appears to be primarily due to the efflux component. Furthermore, subjects with a high erythrocyte to medium lithium concentration ratio had lower rates of both lithium influx and efflux than other subjects, implying that low rates of lithium efflux from erythrocytes cause certain individuals to exhibit high distribution ratios.

Original languageEnglish (US)
Pages (from-to)271-282
Number of pages12
JournalCommunications in Psychopharmacology
Volume1
Issue number3
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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