Computational prediction of microRNA regulatory pathways

Dong Yue, Yidong Chen, Shou Jiang Gao, Yufei Huang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

MicroRNAs (miRNAs) are known to regulate transcription and/or protein translation of hundreds of genes. Despite their importance, the functions of most human miRNAs are still poorly understood. In this paper, we proposed a SVM based algorithm - PathMicrO that elucidates the miRNA function by predicting the miRNA regulated pathways. PathMicrO combines the sequence-level target predictions with the gene expression profiling from the miRNA transfection experiments. The performance of PathMicrO is evaluated with cross-validation using a careful constructed training data. Compared to other prediction algorithms, PathMicrO attains 43.2% improvement in precision when recall is equal to 0.2 and achieves much larger area under the receiver operating characteristic (ROC) curve.

Original languageEnglish (US)
Title of host publication2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010
Pages386-391
Number of pages6
DOIs
StatePublished - Dec 1 2010
Event2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010 - HongKong, China
Duration: Dec 18 2010Dec 21 2010

Publication series

Name2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010

Other

Other2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010
CountryChina
CityHongKong
Period12/18/1012/21/10

Keywords

  • Function
  • MicroRNA
  • PathmicrO
  • Pathway
  • SVM

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics

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