Computational prediction of microRNA regulatory pathways

Dong Yue, Yidong Chen, Shou Jiang Gao, Yufei Huang

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Scopus citations

    Abstract

    MicroRNAs (miRNAs) are known to regulate transcription and/or protein translation of hundreds of genes. Despite their importance, the functions of most human miRNAs are still poorly understood. In this paper, we proposed a SVM based algorithm - PathMicrO that elucidates the miRNA function by predicting the miRNA regulated pathways. PathMicrO combines the sequence-level target predictions with the gene expression profiling from the miRNA transfection experiments. The performance of PathMicrO is evaluated with cross-validation using a careful constructed training data and two independent testing data. Compared to other prediction algorithms, PathMicrO attains 77% more in sensitivity when false positive rate is equal to 0.21 and achieves much larger area under the receiver operating characteristic (ROC) curve.

    Original languageEnglish (US)
    Title of host publicationProceedings 2011 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'11
    PublisherIEEE Computer Society
    Pages158-161
    Number of pages4
    ISBN (Print)9781467304900
    DOIs
    StatePublished - 2011
    Event2011 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'11 - San Antonio, TX, United States
    Duration: Dec 4 2011Dec 6 2011

    Publication series

    NameProceedings - IEEE International Workshop on Genomic Signal Processing and Statistics
    ISSN (Print)2150-3001
    ISSN (Electronic)2150-301X

    Other

    Other2011 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'11
    Country/TerritoryUnited States
    CitySan Antonio, TX
    Period12/4/1112/6/11

    Keywords

    • Function
    • PathmicrO
    • Pathway
    • SVM
    • microRNA

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology (miscellaneous)
    • Computational Theory and Mathematics
    • Signal Processing
    • Biomedical Engineering

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