Computational prediction of microRNA regulatory pathways

Dong Yue, Yidong Chen, Shou Jiang Gao, Yufei Huang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

MicroRNAs (miRNAs) are known to regulate transcription and/or protein translation of hundreds of genes. Despite their importance, the functions of most human miRNAs are still poorly understood. In this paper, we proposed a SVM based algorithm - PathMicrO that elucidates the miRNA function by predicting the miRNA regulated pathways. PathMicrO combines the sequence-level target predictions with the gene expression profiling from the miRNA transfection experiments. The performance of PathMicrO is evaluated with cross-validation using a careful constructed training data and two independent testing data. Compared to other prediction algorithms, PathMicrO attains 77% more in sensitivity when false positive rate is equal to 0.21 and achieves much larger area under the receiver operating characteristic (ROC) curve.

Original languageEnglish (US)
Title of host publicationProceedings 2011 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'11
Pages158-161
Number of pages4
StatePublished - Dec 1 2011
Event2011 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'11 - San Antonio, TX, United States
Duration: Dec 4 2011Dec 6 2011

Publication series

NameProceedings - IEEE International Workshop on Genomic Signal Processing and Statistics
ISSN (Print)2150-3001
ISSN (Electronic)2150-301X

Other

Other2011 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'11
CountryUnited States
CitySan Antonio, TX
Period12/4/1112/6/11

Keywords

  • Function
  • PathmicrO
  • Pathway
  • SVM
  • microRNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Computational Theory and Mathematics
  • Signal Processing
  • Biomedical Engineering

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  • Cite this

    Yue, D., Chen, Y., Gao, S. J., & Huang, Y. (2011). Computational prediction of microRNA regulatory pathways. In Proceedings 2011 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'11 (pp. 158-161). [6169469] (Proceedings - IEEE International Workshop on Genomic Signal Processing and Statistics).