@article{237dd6adc3cf4e00b3315e97c28f1f23,
title = "Compression-resistant polymer/ceramic composite scaffolds augmented with rhBMP-2 promote new bone formation in a nonhuman primate mandibular ridge augmentation model",
abstract = "Purpose: This study was designed to test the hypothesis that compression-: resistant (CR) scaffolds augmented with recombinant human bone morphogenetic protein-2 (rhBMP-2) at clinically relevant doses in a nonhuman primate lateral ridge augmentation model enhances bone formation in a dose-responsive manner without additional protective membranes. Materials and Methods: Defects (15 mm long × 8 mm wide × 5 mm deep) were created bilaterally in the mandibles of nine hamadryas baboons. The defect sites were implanted with poly(ester urethane) (PEUR)/ceramic CR scaffolds augmented with 0 mg/mL rhBMP-2 (CR control), 0.75 mg/mL rhBMP-2 (CR-L), or 1.5 mg/mL rhBMP-2 (CR-H). The primary outcome of ridge width and secondary outcomes of new bone formation, cellular infiltration, and integration with host bone were evaluated using histology, histomorphometry, and microcomputed tomography (micro-CT) at 16 weeks following implantation. Results: New bone formation in the mandible was observed in a dose-responsive manner. CR-H promoted significantly greater new bone formation compared with the CR control group. In all groups, ridge width was maintained without an additional protective membrane. Conclusion: CR scaffolds augmented with a clinically relevant dose of rhBMP-2 (1.5 mg/mL) promoted significant new bone formation. These results suggest that a CR PEUR/ ceramic composite scaffold without a protective membrane may be a potential new rhBMP-2 carrier for clinical use.",
keywords = "Bone graft, Bone morphogenetic proteins, Compression-resistant, Histology, Nonhuman primate, Polymer, Ridge augmentation",
author = "Boller, {Lauren A.} and Jones, {Archie A.} and Cochran, {David L.} and Guelcher, {Scott A.}",
note = "Funding Information: The authors acknowledge Dr Pablo Morales at The Mannheimer Foundation for his assistance with animal husbandry and Ms Katar-zyna Zienkiewicz for her assistance with the preparation of histologic sections. This work was supported by the Army, Navy, National Institutes of Health, Air Force, VA, and Health Affairs to support the AFIRM II effort, under Award No. W81XWH-14-2-0004. The U.S. Army Medical Research Acquisition Activity is the awarding and administering acquisition office. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the Department of Defense. Research reported in this publication was also supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health under Award Number T32DK101003. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors reported no conflicts of interest related to this study. Funding Information: The authors acknowledge Dr Pablo Morales at The Mannheimer Foundation for his assistance with animal husbandry and Ms Katarzyna Zienkiewicz for her assistance with the preparation of histologic sections. This work was supported by the Army, Navy, National Institutes of Health, Air Force, VA, and Health Affairs to support the AFIRM II effort, under Award No. W81XWH-14-2-0004. The U.S. Army Medical Research Acquisition Activity is the awarding and administering acquisition office. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the Department of Defense. Research reported in this publication was also supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health under Award Number T32DK101003. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors reported no conflicts of interest related to this study. Publisher Copyright: {\textcopyright} 2020 by Quintessence Publishing Co Inc.",
year = "2020",
doi = "10.11607/jomi.7877",
language = "English (US)",
volume = "35",
pages = "616--624",
journal = "The International journal of oral & maxillofacial implants",
issn = "0882-2786",
publisher = "Quintessence Publishing Company",
number = "3",
}