Compression-resistant polymer/ceramic composite scaffolds augmented with rhBMP-2 promote new bone formation in a nonhuman primate mandibular ridge augmentation model

Lauren A. Boller, Archie A. Jones, David L. Cochran, Scott A. Guelcher

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: This study was designed to test the hypothesis that compression-: resistant (CR) scaffolds augmented with recombinant human bone morphogenetic protein-2 (rhBMP-2) at clinically relevant doses in a nonhuman primate lateral ridge augmentation model enhances bone formation in a dose-responsive manner without additional protective membranes. Materials and Methods: Defects (15 mm long × 8 mm wide × 5 mm deep) were created bilaterally in the mandibles of nine hamadryas baboons. The defect sites were implanted with poly(ester urethane) (PEUR)/ceramic CR scaffolds augmented with 0 mg/mL rhBMP-2 (CR control), 0.75 mg/mL rhBMP-2 (CR-L), or 1.5 mg/mL rhBMP-2 (CR-H). The primary outcome of ridge width and secondary outcomes of new bone formation, cellular infiltration, and integration with host bone were evaluated using histology, histomorphometry, and microcomputed tomography (micro-CT) at 16 weeks following implantation. Results: New bone formation in the mandible was observed in a dose-responsive manner. CR-H promoted significantly greater new bone formation compared with the CR control group. In all groups, ridge width was maintained without an additional protective membrane. Conclusion: CR scaffolds augmented with a clinically relevant dose of rhBMP-2 (1.5 mg/mL) promoted significant new bone formation. These results suggest that a CR PEUR/ ceramic composite scaffold without a protective membrane may be a potential new rhBMP-2 carrier for clinical use.

Original languageEnglish (US)
Pages (from-to)616-624
Number of pages9
JournalInternational Journal of Oral and Maxillofacial Implants
Volume35
Issue number3
DOIs
StatePublished - 2020

Keywords

  • Bone graft
  • Bone morphogenetic proteins
  • Compression-resistant
  • Histology
  • Nonhuman primate
  • Polymer
  • Ridge augmentation

ASJC Scopus subject areas

  • Oral Surgery

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