Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

Qiwei Yang, Michal Ciebiera, Maria Victoria Bariani, Mohamed Ali, Hoda Elkafas, Thomas G. Boyer, Ayman Al-Hendy

Research output: Contribution to journalReview articlepeer-review

77 Scopus citations


Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the most common tumors in women worldwide. To date, no long-term or noninvasive treatment option exists for hormone-dependent uterine fibroids, due to the limited knowledge about the molecular mechanisms underlying the initiation and development of uterine fibroids. This paper comprehensively summarizes the recent research advances on uterine fibroids, focusing on risk factors, development origin, pathogenetic mechanisms, and treatment options. Additionally, we describe the current treatment interventions for uterine fibroids. Finally, future perspectives on uterine fibroids studies are summarized. Deeper mechanistic insights into tumor etiology and the complexity of uterine fibroids can contribute to the progress of newer targeted therapies.

Original languageEnglish (US)
Pages (from-to)678-719
Number of pages42
JournalEndocrine Reviews
Issue number4
StatePublished - Aug 1 2022


  • developmental origin
  • epigenetics pathways
  • future directions
  • genetic instability
  • novel treatment
  • reprogramming
  • uterine fibroids

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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