Comprehensive investigation of connectivity map data-towards a drug mode of action network for personalized thnerapy

Chifeng Ma, Yufei Huang, Huang I. Harry, Yidong Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This work aims at addressing the problems existed in the original cMap algorithm and proposed a new drug Mode-of Action Network construction scheme including data pre-processing, signature gene extraction, network construction and query prediction. Multiple analyses were conducted to investigate the structure of constructed drug mode-of-action network and the cMap based Mode-of-Action network is tested on the independent drug treatment datasets. All result shows our cMap based drug Mode-of-Action network is both statistically and biologically significant and out-perform the original cMap project.

Original languageEnglish (US)
Title of host publication2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
Pages1045-1047
Number of pages3
DOIs
StatePublished - Dec 1 2011
Event2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011 - Atlanta, GA, United States
Duration: Nov 12 2011Nov 15 2011

Publication series

Name2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011

Other

Other2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
CountryUnited States
CityAtlanta, GA
Period11/12/1111/15/11

Keywords

  • Drug Mode of Action
  • Network and Prediction

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

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  • Cite this

    Ma, C., Huang, Y., Harry, H. I., & Chen, Y. (2011). Comprehensive investigation of connectivity map data-towards a drug mode of action network for personalized thnerapy. In 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011 (pp. 1045-1047). [6112555] (2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011). https://doi.org/10.1109/BIBMW.2011.6112555