Composition of the extracellular matrix of the peritoneum

Craig A. Witz, Iris A. Montoya-Rodriguez, Sook Cho, Victoria E. Centonze, Lynda F. Bonewald, Robert S. Schenken

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


Objective: To localize the extracellular matrix proteins collagen I, collagen IV, fibronectin, and laminin in the peritoneal membrane. Study Design: Peritoneal biopsies (n = 13) from the anterior abdominal wall and the uterine serosa (n = 3) were incubated with antibodies to collagen IV, laminin, collagen I, and fibronectin. Specimens were examined using light and confocal laser scanning microscopy. Results: All of the extracellular matrix (ECM) proteins were present immediately under the mesothelium. Collagen (Col) IV and laminin (LM) were seen in the smooth muscle of microvascular structures, in the subendothelial basement membrane, and were present in a fascicular pattern in the peritoneal stroma. Collagen I was distributed diffusely in the peritoneal stroma. Fibronectin was also present in the subendothelial basement membrane. Conclusions: The resolution of the confocal microscope allowed for localization of extracellular matrix proteins in relation to the mesothelium. The presence of collagen IV, laminin, collagen I, and fibronectin under the mesothelium suggests that cells invading the peritoneum must have the ability to degrade and remodel this matrix.

Original languageEnglish (US)
Pages (from-to)299-304
Number of pages6
JournalJournal of the Society for Gynecologic Investigation
Issue number5
StatePublished - Sep 10 2001


  • Cancer metastasis
  • Collagen
  • Confocal microscopy
  • Endometriosis
  • Fibronectin
  • Laminin
  • Peritoneum

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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