Components of the metabolic syndrome (MTS), hyperinsulinemia, and insulin resistance in obese Israeli children and adolescents

Pnina Vardi, Keren Shahaf-Alkalai, Elliot Sprecher, Ilana Koren, Zvi Zadik, Muhammad Sabbah, Oscar Minuchin, Aaron Lerner, Ladislav Slezak, Muhammad A Abdul-ghani

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The metabolic syndrome (MTS) is important risk factor for cardiovascular disease in adults and until recently, it was rarely described in children. Aim: The aim of our study was to evaluate the frequency of individual MTS components in obese children, and determine risk factors for their early development. Subjects and methods: Data of 374 obese children (mean age of 11.4 ± 2.3 years), (f/m = 211/163), (BMI ≥ 95th percentile) were included in the study, of whom 242 were >10 years. Nine adolescents were referred with overt diabetes. All subjects underwent full clinical and laboratory evaluation, and their data was compared to 191, age, and sex-matched healthy lean controls. Data of OGTT performed on 111 obese children (101 >10 years) and 66, age- and sex-matched healthy controls (22 >10 years) was analyzed. Insulin secretion and insulin sensitivity were determined with validated OGTT derived indices. Results: Results of OGTT showed that 3/101 (3%) adolescents had diabetes, 8 (8%) impaired glucose tolerance (IGT), and 4 (4.%), impaired fasting glucose (IFG) A significantly higher frequency of MTS components was found in obese children when compared to controls, not always associated with insulin resistance. Predictors of early/full presentation of MTS components included: BMI > 33; family history of T2DM; female gender; age >15 years; elevated fasting insulin, and insulin resistance. Conclusion: About 50% of obese children in Israel present one or more MTS components, and 15% have CHO intolerance. Early and full MTS development seems to be associated with family history of T2DM. In obese prepubertal children development of MTS components are independent of hyperinsulinemia and insulin resistance.

Original languageEnglish (US)
Pages (from-to)97-103
Number of pages7
JournalDiabetes and Metabolic Syndrome: Clinical Research and Reviews
Volume1
Issue number2
DOIs
StatePublished - Jun 2007
Externally publishedYes

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Hyperinsulinism
Insulin Resistance
Glucose Tolerance Test
Fasting
Insulin
Glucose Intolerance
Israel
Child Development
Cardiovascular Diseases
Glucose

Keywords

  • Carbohydrate intolerance
  • Children
  • Insulin resistance
  • Metabolic syndrome
  • Obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Components of the metabolic syndrome (MTS), hyperinsulinemia, and insulin resistance in obese Israeli children and adolescents. / Vardi, Pnina; Shahaf-Alkalai, Keren; Sprecher, Elliot; Koren, Ilana; Zadik, Zvi; Sabbah, Muhammad; Minuchin, Oscar; Lerner, Aaron; Slezak, Ladislav; Abdul-ghani, Muhammad A.

In: Diabetes and Metabolic Syndrome: Clinical Research and Reviews, Vol. 1, No. 2, 06.2007, p. 97-103.

Research output: Contribution to journalArticle

Vardi, P, Shahaf-Alkalai, K, Sprecher, E, Koren, I, Zadik, Z, Sabbah, M, Minuchin, O, Lerner, A, Slezak, L & Abdul-ghani, MA 2007, 'Components of the metabolic syndrome (MTS), hyperinsulinemia, and insulin resistance in obese Israeli children and adolescents', Diabetes and Metabolic Syndrome: Clinical Research and Reviews, vol. 1, no. 2, pp. 97-103. https://doi.org/10.1016/j.dsx.2007.02.002
Vardi, Pnina ; Shahaf-Alkalai, Keren ; Sprecher, Elliot ; Koren, Ilana ; Zadik, Zvi ; Sabbah, Muhammad ; Minuchin, Oscar ; Lerner, Aaron ; Slezak, Ladislav ; Abdul-ghani, Muhammad A. / Components of the metabolic syndrome (MTS), hyperinsulinemia, and insulin resistance in obese Israeli children and adolescents. In: Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 2007 ; Vol. 1, No. 2. pp. 97-103.
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AU - Shahaf-Alkalai, Keren

AU - Sprecher, Elliot

AU - Koren, Ilana

AU - Zadik, Zvi

AU - Sabbah, Muhammad

AU - Minuchin, Oscar

AU - Lerner, Aaron

AU - Slezak, Ladislav

AU - Abdul-ghani, Muhammad A

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AB - Background: The metabolic syndrome (MTS) is important risk factor for cardiovascular disease in adults and until recently, it was rarely described in children. Aim: The aim of our study was to evaluate the frequency of individual MTS components in obese children, and determine risk factors for their early development. Subjects and methods: Data of 374 obese children (mean age of 11.4 ± 2.3 years), (f/m = 211/163), (BMI ≥ 95th percentile) were included in the study, of whom 242 were >10 years. Nine adolescents were referred with overt diabetes. All subjects underwent full clinical and laboratory evaluation, and their data was compared to 191, age, and sex-matched healthy lean controls. Data of OGTT performed on 111 obese children (101 >10 years) and 66, age- and sex-matched healthy controls (22 >10 years) was analyzed. Insulin secretion and insulin sensitivity were determined with validated OGTT derived indices. Results: Results of OGTT showed that 3/101 (3%) adolescents had diabetes, 8 (8%) impaired glucose tolerance (IGT), and 4 (4.%), impaired fasting glucose (IFG) A significantly higher frequency of MTS components was found in obese children when compared to controls, not always associated with insulin resistance. Predictors of early/full presentation of MTS components included: BMI > 33; family history of T2DM; female gender; age >15 years; elevated fasting insulin, and insulin resistance. Conclusion: About 50% of obese children in Israel present one or more MTS components, and 15% have CHO intolerance. Early and full MTS development seems to be associated with family history of T2DM. In obese prepubertal children development of MTS components are independent of hyperinsulinemia and insulin resistance.

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KW - Insulin resistance

KW - Metabolic syndrome

KW - Obesity

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