Complications of umbilical artery catheterization in a model of extreme prematurity

R. M. McAdams, V. T. Winter, Donald C Mccurnin, J. J. Coalson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: Umbilical artery catheter (UAC) use is common in the management of critically ill neonates; however, little information exists regarding the anatomic and vascular effects of UAC placement in premature newborns. Study Design: Baboons were delivered at 125 days of gestation (term=185 days), treated with surfactant, had UACs placed and were ventilated for either 6 or 14 days. Animals were assigned to short-term (6 days, n=6) and long-term (14 days, n=30) UAC placement. At necropsy, aortas were removed with UACs still in place. Histological examination of upper, middle and lower aorta specimens stained with hematoxylin and eosin and immunolabeled to detect smooth muscle (α-actin) was carried out in a blinded manner. Controls were delivered at 125, 140 and 185 days and the aortas acquired immediately after birth. None of the non-catheterized control animals (125 days, n=4; 140 days, n=5; and 185 days, n=5) had aortic vessel thrombi or vascular wall abnormalities. Result: All 6 animals with short-term (6/6, 100%) and 18 animals with long-term (18/30, 60%) UAC placement displayed aortic thrombi and neointimal proliferation of the vascular wall. The majority (60%) of analyzed animals with UAC placement displaying neointimal hyperplasia were immunopositive for α-actin, indicating the presence of smooth muscle in these lesions. Conclusion: Our findings suggest that both short- and long-term UAC use is associated with aortic wall pathological abnormalities compared with control animals. This study emphasizes the judicious use and early removal of UACs if possible in order to potentially prevent significant hemostatic and aortic wall vascular complications.

Original languageEnglish (US)
Pages (from-to)685-692
Number of pages8
JournalJournal of Perinatology
Volume29
Issue number10
DOIs
StatePublished - 2009

Fingerprint

Umbilical Arteries
Catheterization
Catheters
Blood Vessels
Aorta
Smooth Muscle
Actins
Thrombosis
Papio
Hemostatics
Hematoxylin
Eosine Yellowish-(YS)
Critical Illness
Surface-Active Agents
Hyperplasia
Parturition
Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

McAdams, R. M., Winter, V. T., Mccurnin, D. C., & Coalson, J. J. (2009). Complications of umbilical artery catheterization in a model of extreme prematurity. Journal of Perinatology, 29(10), 685-692. https://doi.org/10.1038/jp.2009.73

Complications of umbilical artery catheterization in a model of extreme prematurity. / McAdams, R. M.; Winter, V. T.; Mccurnin, Donald C; Coalson, J. J.

In: Journal of Perinatology, Vol. 29, No. 10, 2009, p. 685-692.

Research output: Contribution to journalArticle

McAdams, RM, Winter, VT, Mccurnin, DC & Coalson, JJ 2009, 'Complications of umbilical artery catheterization in a model of extreme prematurity', Journal of Perinatology, vol. 29, no. 10, pp. 685-692. https://doi.org/10.1038/jp.2009.73
McAdams, R. M. ; Winter, V. T. ; Mccurnin, Donald C ; Coalson, J. J. / Complications of umbilical artery catheterization in a model of extreme prematurity. In: Journal of Perinatology. 2009 ; Vol. 29, No. 10. pp. 685-692.
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