Complications of Immunosuppressive Therapy in Solid Organ Transplantation

Venkata Katabathina, Christine O. Menias, Perry Pickhardt, Meghan Lubner, Srinivasa R. Prasad

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Availability of novel immunosuppressive drugs is the most important factor responsible for significant improvement in long-term graft survival rates after solid organ transplantation. However, chronic immunosuppression predisposes patients to a myriad of potentially life-threatening complications. In addition to drug-related adverse effects, transplant recipients are at increased risk of developing opportunistic microbial infections and a spectrum of unique cancers, many of which are caused by oncogenic viruses. Cross-sectional imaging studies play a crucial role in the timely diagnosis and management of post-transplant infections and malignancies.

Original languageEnglish (US)
Pages (from-to)303-319
Number of pages17
JournalRadiologic Clinics of North America
Volume54
Issue number2
DOIs
StatePublished - Mar 1 2016

Keywords

  • Complications
  • Computed tomography
  • Immunosuppression
  • Infections
  • Malignancy
  • MR imaging
  • Posttransplant lymphoproliferative disorder (PTLD)
  • Transplantation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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