Complications of Diabetes Therapy

Sarah D. Corathers, Shawn Peavie, Marzieh Salehi

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Current strategies for the treatment of type 2 diabetes mellitus promote individualized plans to achieve target glucose levels on a patient-by-patient basis while minimizing treatment related risks. Maintaining glycemic control over time is a significant challenge because of the progressive nature of diabetes as a result of declining β-cell function. This article identifies complications of non-insulin treatments for diabetes. The major classes of medications are reviewed with special focus on target population, mechanism of action, effect on weight, cardiovascular outcomes and additional class-specific side effects including effects on bone. Effects on β-cell function are also highlighted.

Original languageEnglish (US)
Pages (from-to)947-970
Number of pages24
JournalEndocrinology and Metabolism Clinics of North America
Issue number4
StatePublished - Dec 2013
Externally publishedYes


  • Cardiovascular outcomes
  • Diabetes
  • Treatment complications
  • β-cell function

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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