Complex/variant translocations in chronic myelogenous leukemia (CML): Genesis and prognosis with 4 new cases

Christina Mendiola, Veronica Ortega, Vijay S. Tonk, Jean M. Coviello, Gopalrao Velagaleti

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

In 5-10% of cases with CML, variant or complex translocations (CT) are seen that may result in atypical fluorescence in situ hybridization signal patterns. Dual color, dual fusion fluorescence in situ hybridization (D-FISH) patterns are instrumental in identifying the genesis of these CT, but their prognostic implications remain controversial. The most common mechanism is a two-step process in which a standard two-way translocation (9;22) is followed by subsequent rearrangements involving other chromosomes. The second common mechanism is the one-step process wherein breakage occurs simultaneously on different chromosomes leading to CT. The typical D-FISH pattern seen with the one-step mechanism is 1F2G2R, while the pattern for the two-step mechanism can be variable (2F1G1R, 1F1G1R, 1F1G2R, 1F2G1R, etc.). We have studied 4 cases of CT using metaphase FISH with triple color, dual fusion ASS1, ABL1 and BCR probes to understand the genesis of these CT. All the patients were treated with imatinib, but only patients 3 and 4 showed remission. Our results indicate that the CT in cases 1, 3 and 4 arose from a one-step mechanism and case 2 from a multi-step mechanism. Response to imatinib varied from full remission to no response. Long term follow-up is necessary to evaluate the prognostic implications of these CT.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalExperimental and Molecular Pathology
Volume97
Issue number1
DOIs
StatePublished - Aug 2014

Keywords

  • BCR/ABL
  • CML
  • Complex rearrangement
  • D-FISH
  • Variant translocation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

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