Complexity of the RAR‐mediated transcriptional regulatory programs

Zhijie Liu, Qidong Hu, Michael G. Rosenfeld

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


In the past several decades, intensive research in this field has uncovered a surprising number of regulatory factors and their associated enzymatic properties to reveal the network of complexes that function in activation and repression of the transcriptional programs mediated by nuclear receptors (NR). These factors and their associated complexes have been extensively characterized both biochemically and functionally [34, 87, 94]. Several principles have emerged: (1) It is widely recognized that ligand-dependent cofactor complexes mediating repression and activation exhibit ligand-dependent exchange. (2) These complexes mediate modifications of chromatin structure consequent to their binding at regulatory elements, particularly at promoter and enhancer sites. (3) The concept about the rapid exchange of coregulatory complexes at regulatory sites has been suggested [88].

Original languageEnglish (US)
Pages (from-to)203-225
Number of pages23
JournalSub-cellular biochemistry
StatePublished - May 29 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Cancer Research


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