TY - JOUR
T1 - Complexity of the RAR‐mediated transcriptional regulatory programs
AU - Liu, Zhijie
AU - Hu, Qidong
AU - Rosenfeld, Michael G.
N1 - Publisher Copyright:
© Springer Science+Business Media Dordrecht 2014.
PY - 2014/5/29
Y1 - 2014/5/29
N2 - In the past several decades, intensive research in this field has uncovered a surprising number of regulatory factors and their associated enzymatic properties to reveal the network of complexes that function in activation and repression of the transcriptional programs mediated by nuclear receptors (NR). These factors and their associated complexes have been extensively characterized both biochemically and functionally [34, 87, 94]. Several principles have emerged: (1) It is widely recognized that ligand-dependent cofactor complexes mediating repression and activation exhibit ligand-dependent exchange. (2) These complexes mediate modifications of chromatin structure consequent to their binding at regulatory elements, particularly at promoter and enhancer sites. (3) The concept about the rapid exchange of coregulatory complexes at regulatory sites has been suggested [88].
AB - In the past several decades, intensive research in this field has uncovered a surprising number of regulatory factors and their associated enzymatic properties to reveal the network of complexes that function in activation and repression of the transcriptional programs mediated by nuclear receptors (NR). These factors and their associated complexes have been extensively characterized both biochemically and functionally [34, 87, 94]. Several principles have emerged: (1) It is widely recognized that ligand-dependent cofactor complexes mediating repression and activation exhibit ligand-dependent exchange. (2) These complexes mediate modifications of chromatin structure consequent to their binding at regulatory elements, particularly at promoter and enhancer sites. (3) The concept about the rapid exchange of coregulatory complexes at regulatory sites has been suggested [88].
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U2 - 10.1007/978-94-017-9050-5_10
DO - 10.1007/978-94-017-9050-5_10
M3 - Article
C2 - 24962887
AN - SCOPUS:84910141042
SN - 0306-0225
VL - 70
SP - 203
EP - 225
JO - Sub-cellular biochemistry
JF - Sub-cellular biochemistry
ER -