Complexes of platinum(II) or palladium(II) with 1,10-phenanthroline and amino acids

Victor X. Jin, John D. Ranford

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

The amino acids complexes of [Pt(phen)(AA)]NO3·xH2O and [Pd(phen)(AA)]NO3·xH2O have been prepared by the interaction of palladium and platinum complexes, [Pt(phen)Cl2] and [Pd(phen)Cl2] with salts of amino acids in methanol and characterized by 1H NMR and IR spectroscopy which confirmed the formation of a very large variety of compounds with ligand in a simple way (bidentate). All of these new compounds have been isolated and tested for cytotoxicity on Molt-4, a human leukaemia cell line. The IC50 values of [Pt(phen)(Pro)]Cl·2H2O and [Pd(phen)(Asp)]Cl·1.5H2O are 9.8 and 7.31 μM, respectively, exhibiting a significant activity which is close to cis-[PtCl2(NH3)2]. (C) 2000 Elsevier Science S.A.

Original languageEnglish (US)
Pages (from-to)38-44
Number of pages7
JournalInorganica Chimica Acta
Volume304
Issue number1
DOIs
StatePublished - Jun 15 2000
Externally publishedYes

Keywords

  • Amino acid complexes
  • Palladium complexes
  • Phenanthroline complexes
  • Platinum complexes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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