Abstract
The complete covalent structure has been determined for a human myeloma IgA1 immunoglobulin. This protein has unique features in the amino acid sequence and disulfide bridge structure of the variable (V) and constant (C) regions of both the α heavy and the λ light chains, and in the number and loci of oligosaccharides. Whereas C region domains of heavy chains have evolved independently over eons, recent isotypic variations have occurred in λ light chains and possibly in a heavy chains.
Original language | English (US) |
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Pages (from-to) | 1017-1020 |
Number of pages | 4 |
Journal | Science |
Volume | 193 |
Issue number | 4257 |
DOIs | |
State | Published - 1976 |
Externally published | Yes |
ASJC Scopus subject areas
- General