Complete covalent structure of a human IgA1 immunoglobulin

Yu Sheng Victor Liu, Teresa L K Low, Anthony J Infante, Frank W. Putnam

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The complete covalent structure has been determined for a human myeloma IgA1 immunoglobulin. This protein has unique features in the amino acid sequence and disulfide bridge structure of the variable (V) and constant (C) regions of both the α heavy and the λ light chains, and in the number and loci of oligosaccharides. Whereas C region domains of heavy chains have evolved independently over eons, recent isotypic variations have occurred in λ light chains and possibly in a heavy chains.

Original languageEnglish (US)
Pages (from-to)1017-1020
Number of pages4
JournalScience
Volume193
Issue number4257
StatePublished - 1976
Externally publishedYes

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Immunoglobulin A
Immunoglobulins
Light
Oligosaccharides
Disulfides
Amino Acid Sequence
Proteins
myeloma immunoglobulins

ASJC Scopus subject areas

  • General

Cite this

Liu, Y. S. V., Low, T. L. K., Infante, A. J., & Putnam, F. W. (1976). Complete covalent structure of a human IgA1 immunoglobulin. Science, 193(4257), 1017-1020.

Complete covalent structure of a human IgA1 immunoglobulin. / Liu, Yu Sheng Victor; Low, Teresa L K; Infante, Anthony J; Putnam, Frank W.

In: Science, Vol. 193, No. 4257, 1976, p. 1017-1020.

Research output: Contribution to journalArticle

Liu, YSV, Low, TLK, Infante, AJ & Putnam, FW 1976, 'Complete covalent structure of a human IgA1 immunoglobulin', Science, vol. 193, no. 4257, pp. 1017-1020.
Liu YSV, Low TLK, Infante AJ, Putnam FW. Complete covalent structure of a human IgA1 immunoglobulin. Science. 1976;193(4257):1017-1020.
Liu, Yu Sheng Victor ; Low, Teresa L K ; Infante, Anthony J ; Putnam, Frank W. / Complete covalent structure of a human IgA1 immunoglobulin. In: Science. 1976 ; Vol. 193, No. 4257. pp. 1017-1020.
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