Complement, innate immunity and ocular disease

Jeong Hyeon Sohn, Puran S. Bora, Prushottam Jha, Tongalp H. Tezel, Henry J. Kaplan, Nalini S. Bora

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Scopus citations

Abstract

The complement system is a major component of innate immunity. During an inflammatory reaction, the eye is potentially threatened by homologous complement attack, and unregulated complement activation could lead to tissue damage and vision loss. The complement system is continuously activated at low levels in the normal eye, and intraocular complement-regulatory proteins (CRPs) tightly regulate this spontaneous complement activation so that there is elimination of potential pathogens without the induction of destructive intraocular inflammation. The presence of a complement activation product (iC3b) during the early phase of antigen and antigen-presenting cell contact is essential for the induction of systemic tolerance to antigen injected into the anterior chamber of the eye and the establishment of ocular immune privilege. The complement system and complement-regulatory proteins control intraocular inflammation in autoimmune anterior uveitis and may play an important role in the development of age-related macular degeneration. Thus, in the eye, complement functions as a double-edged sword - on one hand it provides innate immunity against pathogens while simultaneously instructing the adaptive immune response to develop tolerance to such pathogens to avoid inadvertent tissue damage in a critical organ.

Original languageEnglish (US)
Title of host publicationImmune Response and the Eye
EditorsJerry Niederkorn, Henry Kaplan
Pages105-114
Number of pages10
DOIs
StatePublished - Jul 30 2007
Externally publishedYes

Publication series

NameChemical Immunology and Allergy
Volume92
ISSN (Print)1660-2242

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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