Comparison of thermogenic effect of fructose and glucose in normal humans

L. Tappy, J. P. Randin, J. P. Felber, R. Chiolero, D. C. Simonson, E. Jequier, R. A. DeFronzo

Research output: Contribution to journalArticlepeer-review

133 Scopus citations

Abstract

After nutrient ingestion there is an increase in energy expenditure that has been referred to as dietary-induced thermogenesis. In the present study we have employed indirect calorimetry to compare the increment in energy expenditure after the ingestion of 75 g of glucose or fructose in 17 healthy volunteers. During the 4 h after glucose ingestion the plasma insulin concentration increased by 33 ± 4 μU/ml and this was associated with a significant increase in carbohydrate oxidation and decrement in lipid oxidation. Energy expenditure increased by 0.08 ± 0.01 kcal/min. When fructose was ingested, the plasma insulin concentration increased by only 8 ± 2 μU/ml vs. glucose. Nonetheless, the increments in carbohydrate oxidation and decrement in lipid oxidation were significantly greater than with glucose. The increment in energy expenditure was also greater with fructose. When the mean increment in plasma insulin concentration after fructose was reproduced using the insulin clamp technique, the increase in carbohydrate oxidation and decrement in lipid oxidation were markedly reduced compared with the fructose-ingestion study; energy expenditure failed to increase above basal levels. To examine the role of the adrenergic nervous system in fructose-induced thermogenesis, fructose ingestion was also performed during β-adrenergic blockade with propranolol. The increase in energy expenditure during fructose plus propranolol was lower than with fructose ingestion alone. These results indicate that the stimulation of thermogenesis after carbohydrate ingestion is related to an augmentation of cellular metabolism and is not dependent on an increase in the plasma insulin concentration per se. Because the increment in energy expenditure after fructose ingestion could be inhibited by 40% with propranolol, it is likely that the β-adrenergic nervous system contributes, at least in part, to fructose-induced thermogenesis.

Original languageEnglish (US)
Pages (from-to)E718-E724
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume250
Issue number6 (13/6)
DOIs
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

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