Event-related functional MRI (ER-fMRI) based on both blood oxygen level- dependent (BOLD) contrast and perfusion contrast has been recently developed to study human brain activation due to brief stimulation. In this report, both BOLD- and perfusion-based ER-fMRI were directly compared using repeated single-trial, short visual stimulation (1 sec) in six human volunteers. The results show that the cerebral blood flow change reached a maximum approximately 1 sec earlier than the BOLD signal change (4.2 ± 0.2 sec vs. 5.1 ± 0.2 sec after the stimulation, P < 0.05). The full width at half maximum of the hemodynamic response measured by perfusion was not significantly different from that measured with BOLD (5.1 ± 0.6 sec vs. 5.9 ± 0.6 sec). A positive linear correlation was found between the maximum perfusion and maximum BOLD signal changes (r = 0.77, P = 0.07). (C) 2000 Wiley-Liss, Inc.
|Original language||English (US)|
|Number of pages||5|
|Journal||Magnetic Resonance in Medicine|
|State||Published - May 17 2000|
- Single trial
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging