Abstract
Event-related functional MRI (ER-fMRI) based on both blood oxygen level- dependent (BOLD) contrast and perfusion contrast has been recently developed to study human brain activation due to brief stimulation. In this report, both BOLD- and perfusion-based ER-fMRI were directly compared using repeated single-trial, short visual stimulation (1 sec) in six human volunteers. The results show that the cerebral blood flow change reached a maximum approximately 1 sec earlier than the BOLD signal change (4.2 ± 0.2 sec vs. 5.1 ± 0.2 sec after the stimulation, P < 0.05). The full width at half maximum of the hemodynamic response measured by perfusion was not significantly different from that measured with BOLD (5.1 ± 0.6 sec vs. 5.9 ± 0.6 sec). A positive linear correlation was found between the maximum perfusion and maximum BOLD signal changes (r = 0.77, P = 0.07). (C) 2000 Wiley-Liss, Inc.
Original language | English (US) |
---|---|
Pages (from-to) | 768-772 |
Number of pages | 5 |
Journal | Magnetic Resonance in Medicine |
Volume | 43 |
Issue number | 5 |
DOIs | |
State | Published - 2000 |
Keywords
- BOLD
- Event-related
- FMRI
- MRI
- Perfusion
- Single trial
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging