Comparison of the temporal response in perfusion and BOLD-based event- related functional MRI

Ho Ling Liu, Yonglin Pu, Lisa D. Nickerson, Yijun Liu, Peter T Fox, Jia Hong Gao

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Event-related functional MRI (ER-fMRI) based on both blood oxygen level- dependent (BOLD) contrast and perfusion contrast has been recently developed to study human brain activation due to brief stimulation. In this report, both BOLD- and perfusion-based ER-fMRI were directly compared using repeated single-trial, short visual stimulation (1 sec) in six human volunteers. The results show that the cerebral blood flow change reached a maximum approximately 1 sec earlier than the BOLD signal change (4.2 ± 0.2 sec vs. 5.1 ± 0.2 sec after the stimulation, P < 0.05). The full width at half maximum of the hemodynamic response measured by perfusion was not significantly different from that measured with BOLD (5.1 ± 0.6 sec vs. 5.9 ± 0.6 sec). A positive linear correlation was found between the maximum perfusion and maximum BOLD signal changes (r = 0.77, P = 0.07). (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)768-772
Number of pages5
JournalMagnetic Resonance in Medicine
Volume43
Issue number5
DOIs
StatePublished - 2000

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Perfusion
Magnetic Resonance Imaging
Oxygen
Cerebrovascular Circulation
Photic Stimulation
Volunteers
Hemodynamics
Brain

Keywords

  • BOLD
  • Event-related
  • FMRI
  • MRI
  • Perfusion
  • Single trial

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Comparison of the temporal response in perfusion and BOLD-based event- related functional MRI. / Liu, Ho Ling; Pu, Yonglin; Nickerson, Lisa D.; Liu, Yijun; Fox, Peter T; Gao, Jia Hong.

In: Magnetic Resonance in Medicine, Vol. 43, No. 5, 2000, p. 768-772.

Research output: Contribution to journalArticle

Liu, Ho Ling ; Pu, Yonglin ; Nickerson, Lisa D. ; Liu, Yijun ; Fox, Peter T ; Gao, Jia Hong. / Comparison of the temporal response in perfusion and BOLD-based event- related functional MRI. In: Magnetic Resonance in Medicine. 2000 ; Vol. 43, No. 5. pp. 768-772.
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