Comparison of the temporal response in perfusion and BOLD-based event- related functional MRI

Ho Ling Liu, Yonglin Pu, Lisa D. Nickerson, Yijun Liu, Peter T. Fox, Jia Hong Gao

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Event-related functional MRI (ER-fMRI) based on both blood oxygen level- dependent (BOLD) contrast and perfusion contrast has been recently developed to study human brain activation due to brief stimulation. In this report, both BOLD- and perfusion-based ER-fMRI were directly compared using repeated single-trial, short visual stimulation (1 sec) in six human volunteers. The results show that the cerebral blood flow change reached a maximum approximately 1 sec earlier than the BOLD signal change (4.2 ± 0.2 sec vs. 5.1 ± 0.2 sec after the stimulation, P < 0.05). The full width at half maximum of the hemodynamic response measured by perfusion was not significantly different from that measured with BOLD (5.1 ± 0.6 sec vs. 5.9 ± 0.6 sec). A positive linear correlation was found between the maximum perfusion and maximum BOLD signal changes (r = 0.77, P = 0.07). (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)768-772
Number of pages5
JournalMagnetic Resonance in Medicine
Volume43
Issue number5
DOIs
StatePublished - May 17 2000

Keywords

  • BOLD
  • Event-related
  • FMRI
  • MRI
  • Perfusion
  • Single trial

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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