Abstract
The abilities of 3-methylcholanthrene (3-MC) and 3,11-dimethylcholanthrene (3,11-DMC) to initiate skin tumors in Sencar mice were determined by using a 2-stage system of tumorigenesis. 3,11-DMC was found to have very weak skin tumor initiating activity when compared to the potent activity of 3-MC. The only difference between 3-MC and 3,11-DMC is the substitution of a methyl group in position 11 which is part of the 'K-region' or the 'peri' position. From these results, we suggest that an unhindered peri position adjacent to an angular benzene ring is necessary for carcinogenic activity of 3-MC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 97-102 |
| Number of pages | 6 |
| Journal | Cancer Letters |
| Volume | 7 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Jul 1979 |
| Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research