@article{a0afbdb6f1ad43f2b19b852bee865a58,
title = "Comparison of the skin tumor initiating activity of 3-methylcholanthrene and 3,11-dimethylcholanthrene in mice",
abstract = "The abilities of 3-methylcholanthrene (3-MC) and 3,11-dimethylcholanthrene (3,11-DMC) to initiate skin tumors in Sencar mice were determined by using a 2-stage system of tumorigenesis. 3,11-DMC was found to have very weak skin tumor initiating activity when compared to the potent activity of 3-MC. The only difference between 3-MC and 3,11-DMC is the substitution of a methyl group in position 11 which is part of the 'K-region' or the 'peri' position. From these results, we suggest that an unhindered peri position adjacent to an angular benzene ring is necessary for carcinogenic activity of 3-MC.",
author = "Slaga, {T. J.} and Gleason, {G. L.} and L. Hardin",
note = "Funding Information: Jerina and coworkers \[10,11\] have proposed a theory which predmts that 'bay region' dlol-epoxides of polycyclic aromatic hydrocarbons (PAH) axe importaxlt in their caxcin,ogenic activity. A bay region occurs m a \]:'~H \[F ig. 1\] when an angularly fused berzo ring is present \[10\]. Recent evidence suggests that bay region dioh.~poxi,~es cf benzo\[a\]p yrene (BP), benz\[a\]a nthracene (BA), chrysene, 7-methyl~enz\[a\]anthracene (7-methyl-B,',), dibenz\[a,h\]-anthracene, and 7,12-dimethylbenz\[a\a] nthracene (DMBA) are highly car-cmogemc and mutagemc \[£,2,5,6.12--22,25--27,29--33\]. Wood et al. \[28\] recently reported that 1,9,10-*~nhydroxy-9,10-dihydro-3-methy\]cholmltbrene *Supported in part by NIH Grant CA-20076 and by the Office of Health artd Envlron-r,~enta\]R esearch, U.S~ Department of Ene~'gy, under contract W-7 i05-eng-26 w~th the Union Carbide Corporation. **To whom reprint requests ~hou\]db e addressed",
year = "1979",
month = jul,
doi = "10.1016/S0304-3835(79)80102-0",
language = "English (US)",
volume = "7",
pages = "97--102",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2-3",
}