Comparison of the disparity between Talairach and MNI coordinates in functional neuroimaging data: Validation of the Lancaster transform

Angela R. Laird, Jennifer L. Robinson, Kathryn M. McMillan, Diana Tordesillas-Gutiérrez, Sarah T. Moran, Sabina M. Gonzales, Kimberly L. Ray, Crystal Franklin, David C. Glahn, Peter T. Fox, Jack L. Lancaster

Research output: Contribution to journalArticlepeer-review

190 Scopus citations

Abstract

Spatial normalization of neuroimaging data is a standard step when assessing group effects. As a result of divergent analysis procedures due to different normalization algorithms or templates, not all published coordinates refer to the same neuroanatomical region. Specifically, the literature is populated with results in the form of MNI or Talairach coordinates, and their disparity can impede the comparison of results across different studies. This becomes particularly problematic in coordinate-based meta-analyses, wherein coordinate disparity should be corrected to reduce error and facilitate literature reviews. In this study, a quantitative comparison was performed on two corrections, the Brett transform (i.e., "mni2tal"), and the Lancaster transform (i.e., "icbm2tal"). Functional magnetic resonance imaging (fMRI) data acquired during a standard paired associates task indicated that the disparity between MNI and Talairach coordinates was better reduced via the Lancaster transform, as compared to the Brett transform. In addition, an activation likelihood estimation (ALE) meta-analysis of the paired associates literature revealed that a higher degree of concordance was obtained when using the Lancaster transform in the form of fewer, smaller, and more intense clusters. Based on these results, we recommend that the Lancaster transform be adopted as the community standard for reducing disparity between results reported as MNI or Talairach coordinates, and suggest that future spatial normalization strategies be designed to minimize this variability in the literature.

Original languageEnglish (US)
Pages (from-to)677-683
Number of pages7
JournalNeuroImage
Volume51
Issue number2
DOIs
StatePublished - Jun 2010

Keywords

  • Brett transform
  • Coordinate disparity
  • Icbm2tal
  • Lancaster transform
  • MNI
  • Mni2tal
  • Spatial normalization
  • Talairach

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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