The elimination of both [14C]phenacetin and amino[14C]pyrine as judged by production of 14CO2 in the breath showed a linear response relationship to the degree of hepatic necrosis. Further there was a differential sensitivity of the elimination of these test compounds to acute and chronic liver injury suggesting a variable susceptibility of the enzymes responsible for their metabolism. The study emphasizes the importance of using Kel rather than half-life when comparing the effect of liver injury on drug metabolism. Finally, the study demonstrates that breath tests will reflect the extent of hepatic damage and may also be used to examine the effect of liver disease on various routes of drug metabolism.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Jun 1980|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)