Comparison of "selective" opiate receptor antagonists on the isolated mouse vas deferens

C. B. Smith, L. Bennett-Kelly, J. H. Woods

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The selectivity and relative potencics of opiate receptor antagonists were compared on the mouse vas deferens preparation. ICI-174864 was found to be a highly selective antagonist at delta opiate receptors equal in potency to naltrexone in blocking the actions of delta agonists. Although less potent than naltrexone, beta-funal trexamine (beta-FNA) and Mr-1452, like naltrexone, were less selective in that they blocked the actions of mu, delta and kappa agonists. The relative potencies of beta-FNA and Mr-1452 in antagonizing the three types of agonists also were similar to naltrexone.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalNeuropeptides
Volume5
Issue number1-3
DOIs
StatePublished - Dec 1984

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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