Comparison of post-mortem urinary and vitreous humour organic acids

Michael J. Bennett, Marie C. Ragni, Ian Hood, Daniel E. Hale

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


We have analysed organic acid profiles in 74 samples of post-mortem vitreous humour from the suddent infant death syndrome and compared the profiles to those obtained from the corresponding urine or bladder wall swab. There was a high degree of correlation indicating that vitreous humour analysis in high-risk infants is an appropriate analytical strategy when urine is not available. In our patient sample two infants had evidence of abnormal methylmalonic acid metabolism, one had glyceric aciduria (and elevated levels of vitreous humour glyceric acid), one had evidence of pre-existing liver damage as judged by the presence of 4-hydroxyphenyllactic acid, one had a non-ketotic dicarboxylic aciduria indicating inhibited fatty acid oxidation and two patients had significant long-chain 3-hydroxydicarboxylic acids and evidence of paracetamol ingestion.

Original languageEnglish (US)
Pages (from-to)541-545
Number of pages5
JournalAnnals of Clinical Biochemistry
Issue number5
StatePublished - Sep 1992
Externally publishedYes


  • gas chromatography/mass spectrometry
  • inborn errors of metabolism
  • metabolic diseases
  • sudden infant death syndrome

ASJC Scopus subject areas

  • Clinical Biochemistry


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