Comparison of oral triazolam and nitrous oxide with placebo and intravenous diazepam for outpatient premedication

Eliezer Kaufman, Kenneth M. Hargreaves, Raymond A. Dionne

Research output: Contribution to journalArticle

13 Scopus citations


Triazolam was evaluated as an oral sedative agent for dental outpatients in two studies in the oral surgery model. The first study demonstrated that 0.25 mg of triazolam in combination with nitrous oxide provides therapeutic effects but with a more rapid recovery than a 0.50 mg dose in combination with nitrous oxide. In the second study, triazolam produced a significant anxiolytic effect that was comparable to the effects of diazepam titrated to the usual clinical endpoint (mean dose = 19.3 mg). Less impairment in cognitive-psychomotor impairment and ambulatory function was seen after triazolam in comparison with diazepam. Triazolam appears to be a safe, effective alternative to parenteral sedation with a benzodiazepine for dental outpatients.

Original languageEnglish (US)
Pages (from-to)156-164
Number of pages9
JournalOral Surgery, Oral Medicine, Oral Pathology
Issue number2
StatePublished - Feb 1993
Externally publishedYes


ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dentistry(all)

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