Comparison of noncontingent versus contingent cocaine administration on plasma corticosterone levels in rats

Ruggero Galici, Robert N. Pechnick, Russell E. Poland, Charles P. France

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

The purpose of the present study was to compare the effects of contingent and noncontingent cocaine administration on plasma levels of corticosterone in rats. Male rats were trained to self-administer cocaine under a fixed-ratio 5 schedule. The rats were yoked such that the delivery of cocaine (0.25 mg/kg/infusion) to one rat (contingent cocaine) produced the simultaneous noncontingent delivery of the same dose of cocaine (noncontingent cocaine) or saline (noncontingent saline) to other rats. Although saline administration had no effect, plasma corticosterone levels were significantly higher in rat receiving contingent cocaine compared to those receiving noncontingent cocaine. These results demonstrate that the active vs. passive administration of cocaine can differentially affect this neuroendocrine response. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)59-62
Number of pages4
JournalEuropean Journal of Pharmacology
Volume387
Issue number1
DOIs
StatePublished - Nov 3 2000
Externally publishedYes

Keywords

  • Cocaine
  • Corticosterone
  • Hypothalamo pituitary-adrenal axis
  • Neuroendocrine
  • Self-administration
  • Stress

ASJC Scopus subject areas

  • Pharmacology

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