TY - JOUR
T1 - Comparison of N-octyl-cyanoacrylate vs suture in the stabilization of cartilage grafts
AU - Brown, Patrick N.
AU - McGuff, H. Stan
AU - Noorily, Allen D.
PY - 1996/8
Y1 - 1996/8
N2 - Objective: To compare N-octyl-cyanoacrylate and suture control to determine the efficacy of this tissue glue preparation in securing grafted cartilage with an acceptable inflammatory reaction. Design: Four 5-mm circular auricular cartilage grafts were harvested, and 2 of these grafts were either glued together with N-octyl-cyanoacrylate or sewn together with nylon suture. These sandwich grafts were then glued or sewn to the periosteum of the calvaria. Histologic analysis for inflammation, necrosis, fibrosis, and foreign-body giant cell reaction was performed 2 and 6 weeks after implantation. We also measured cartilage graft migration from the original site of surgical implantation. Subjects: Sixteen New Zealand white rabbits. The 2-week study group consisted of 7 rabbits (1 died of dehydration), and the 6-week group totaled 8. Intervention: Each rabbit underwent auricular cartilage harvest and cartilage graft implantation to the parietal skull periosteum. Results: We found no histological differences between the glue specimens and the suture controls. Similarly, our examination of graft migration yielded no differences between groups. Conclusions: N-octyl-cyanoacrylate was superior to standard suture technique by virtue of its speed, ease, and accuracy of application. No adverse inflammation was observed. Further studies, including clinical trials, are needed to assess the safety of N-octyl-cyanoacrylate in humans.
AB - Objective: To compare N-octyl-cyanoacrylate and suture control to determine the efficacy of this tissue glue preparation in securing grafted cartilage with an acceptable inflammatory reaction. Design: Four 5-mm circular auricular cartilage grafts were harvested, and 2 of these grafts were either glued together with N-octyl-cyanoacrylate or sewn together with nylon suture. These sandwich grafts were then glued or sewn to the periosteum of the calvaria. Histologic analysis for inflammation, necrosis, fibrosis, and foreign-body giant cell reaction was performed 2 and 6 weeks after implantation. We also measured cartilage graft migration from the original site of surgical implantation. Subjects: Sixteen New Zealand white rabbits. The 2-week study group consisted of 7 rabbits (1 died of dehydration), and the 6-week group totaled 8. Intervention: Each rabbit underwent auricular cartilage harvest and cartilage graft implantation to the parietal skull periosteum. Results: We found no histological differences between the glue specimens and the suture controls. Similarly, our examination of graft migration yielded no differences between groups. Conclusions: N-octyl-cyanoacrylate was superior to standard suture technique by virtue of its speed, ease, and accuracy of application. No adverse inflammation was observed. Further studies, including clinical trials, are needed to assess the safety of N-octyl-cyanoacrylate in humans.
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U2 - 10.1001/archotol.1996.01890200063014
DO - 10.1001/archotol.1996.01890200063014
M3 - Article
C2 - 8703393
AN - SCOPUS:0029766962
VL - 122
SP - 873
EP - 877
JO - JAMA Otolaryngology - Head and Neck Surgery
JF - JAMA Otolaryngology - Head and Neck Surgery
SN - 2168-6181
IS - 8
ER -