Comparison of muscle paralysis after intravenous and intraosseous administration of succinylcholine in Swine

Michael J. Loughren; James Kilbourn; Kevin Worth; James Burgert; Brian Gegel; Don Johnson

Comparison of muscle paralysis after intravenous and intraosseous administration of succinylcholine in Swine

Michael J. Loughren, James Kilbourn, Kevin Worth, James Burgert, Brian Gegel, Don Johnson

Research output: Contribution to journal › Article › peer-review

Abstract

AIM: To compare the onset and duration of intravenous (IV) and intraosseous (IO) administration of succinylcholine in swine.

METHODS: Electromyographic (EMG) amplitudes were used to characterize muscle paralysis following administration of succinylcholine via the IV or IO route in four Yorkshire-cross swine.

RESULTS: The onset of action of succinylcholine was statistically longer after IO administration (0.97±0.40) compared with IV administration (0.55±0.26) (p=.048). Duration of action was unaffected by route of administration: IO, 11.4±4.2, and IV, 12.9±3.8 (p=.65).

CONCLUSIONS: Succinylcholine can be effectively administered via the IO route. However, an increased dose may be necessary when administering succinylcholine via the IO route to achieve the same rapid onset as standard IV dosing.

Original language	English (US)
Pages (from-to)	35-37
Number of pages	3
Journal	Journal of special operations medicine : a peer reviewed journal for SOF medical professionals
Volume	14
Issue number	2
State	Published - Jun 1 2014
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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Comparison of muscle paralysis after intravenous and intraosseous administration of succinylcholine in Swine. / Loughren, Michael J.; Kilbourn, James; Worth, Kevin et al.
In: Journal of special operations medicine : a peer reviewed journal for SOF medical professionals, Vol. 14, No. 2, 01.06.2014, p. 35-37.

Research output: Contribution to journal › Article › peer-review

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abstract = "AIM: To compare the onset and duration of intravenous (IV) and intraosseous (IO) administration of succinylcholine in swine.METHODS: Electromyographic (EMG) amplitudes were used to characterize muscle paralysis following administration of succinylcholine via the IV or IO route in four Yorkshire-cross swine.RESULTS: The onset of action of succinylcholine was statistically longer after IO administration (0.97±0.40) compared with IV administration (0.55±0.26) (p=.048). Duration of action was unaffected by route of administration: IO, 11.4±4.2, and IV, 12.9±3.8 (p=.65).CONCLUSIONS: Succinylcholine can be effectively administered via the IO route. However, an increased dose may be necessary when administering succinylcholine via the IO route to achieve the same rapid onset as standard IV dosing.",

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AU - Loughren, Michael J.

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AU - Burgert, James

AU - Gegel, Brian

AU - Johnson, Don

PY - 2014/6/1

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N2 - AIM: To compare the onset and duration of intravenous (IV) and intraosseous (IO) administration of succinylcholine in swine.METHODS: Electromyographic (EMG) amplitudes were used to characterize muscle paralysis following administration of succinylcholine via the IV or IO route in four Yorkshire-cross swine.RESULTS: The onset of action of succinylcholine was statistically longer after IO administration (0.97±0.40) compared with IV administration (0.55±0.26) (p=.048). Duration of action was unaffected by route of administration: IO, 11.4±4.2, and IV, 12.9±3.8 (p=.65).CONCLUSIONS: Succinylcholine can be effectively administered via the IO route. However, an increased dose may be necessary when administering succinylcholine via the IO route to achieve the same rapid onset as standard IV dosing.

AB - AIM: To compare the onset and duration of intravenous (IV) and intraosseous (IO) administration of succinylcholine in swine.METHODS: Electromyographic (EMG) amplitudes were used to characterize muscle paralysis following administration of succinylcholine via the IV or IO route in four Yorkshire-cross swine.RESULTS: The onset of action of succinylcholine was statistically longer after IO administration (0.97±0.40) compared with IV administration (0.55±0.26) (p=.048). Duration of action was unaffected by route of administration: IO, 11.4±4.2, and IV, 12.9±3.8 (p=.65).CONCLUSIONS: Succinylcholine can be effectively administered via the IO route. However, an increased dose may be necessary when administering succinylcholine via the IO route to achieve the same rapid onset as standard IV dosing.

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Comparison of muscle paralysis after intravenous and intraosseous administration of succinylcholine in Swine

Abstract

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