Comparison of muscle paralysis after intravenous and intraosseous administration of succinylcholine in Swine

Michael J. Loughren, James Kilbourn, Kevin Worth, James Burgert, Brian Gegel, Don Johnson

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

AIM: To compare the onset and duration of intravenous (IV) and intraosseous (IO) administration of succinylcholine in swine.

METHODS: Electromyographic (EMG) amplitudes were used to characterize muscle paralysis following administration of succinylcholine via the IV or IO route in four Yorkshire-cross swine.

RESULTS: The onset of action of succinylcholine was statistically longer after IO administration (0.97±0.40) compared with IV administration (0.55±0.26) (p=.048). Duration of action was unaffected by route of administration: IO, 11.4±4.2, and IV, 12.9±3.8 (p=.65).

CONCLUSIONS: Succinylcholine can be effectively administered via the IO route. However, an increased dose may be necessary when administering succinylcholine via the IO route to achieve the same rapid onset as standard IV dosing.

Original languageEnglish (US)
Pages (from-to)35-37
Number of pages3
JournalJournal of special operations medicine : a peer reviewed journal for SOF medical professionals
Volume14
Issue number2
StatePublished - Jun 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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