TY - JOUR
T1 - Comparison of MICs of fluconazole and flucytosine when dissolved in dimethyl sulfoxide or water
AU - Fothergill, Annette W.
AU - Sanders, Carmita
AU - Wiederhold, Nathan P.
PY - 2013/6
Y1 - 2013/6
N2 - A total of 145 clinical strains of Candida species were tested by the Clinical and Laboratory Standards Institute M27-A3 methodology to determine if replacing water with dimethyl sulfoxide as the solvent for fluconazole and flucytosine impacted the in vitro potency. No significant differences in MIC values were observed with either antifungal between the two solvents against any Candida species, and the essential agreement for each agent between the two solvents was greater than 99%.
AB - A total of 145 clinical strains of Candida species were tested by the Clinical and Laboratory Standards Institute M27-A3 methodology to determine if replacing water with dimethyl sulfoxide as the solvent for fluconazole and flucytosine impacted the in vitro potency. No significant differences in MIC values were observed with either antifungal between the two solvents against any Candida species, and the essential agreement for each agent between the two solvents was greater than 99%.
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U2 - 10.1128/JCM.00260-13
DO - 10.1128/JCM.00260-13
M3 - Article
C2 - 23576540
AN - SCOPUS:84878501073
SN - 0095-1137
VL - 51
SP - 1955
EP - 1957
JO - Journal of clinical microbiology
JF - Journal of clinical microbiology
IS - 6
ER -