Comparison of MICs of fluconazole and flucytosine when dissolved in dimethyl sulfoxide or water

Annette W. Fothergill, Carmita Sanders, Nathan P. Wiederhold

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

A total of 145 clinical strains of Candida species were tested by the Clinical and Laboratory Standards Institute M27-A3 methodology to determine if replacing water with dimethyl sulfoxide as the solvent for fluconazole and flucytosine impacted the in vitro potency. No significant differences in MIC values were observed with either antifungal between the two solvents against any Candida species, and the essential agreement for each agent between the two solvents was greater than 99%.

Original languageEnglish (US)
Pages (from-to)1955-1957
Number of pages3
JournalJournal of clinical microbiology
Volume51
Issue number6
DOIs
StatePublished - Jun 1 2013

ASJC Scopus subject areas

  • Microbiology (medical)

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