Comparison of major protein antigens and protein profiles of Treponema pallidum and Treponema pertenue

R. W. Thornburg, J. B. Baseman

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The protein profiles of Treponema pallidum and Treponema pertenue, the causative agents of syphilis and yaws, respectively, were compared by one- and two-dimensional gel electrophoresis. One-dimensional gels showed essentially no differences in the protein patterns of these treponemes. On two-dimensional gels most radiolabeled protein species were shared; however, variations were noticed in several minor protein species. Antigenic comparison by radioimmunoprecipitation and Western blotting also demonstrated similarities between these spirochetes. However, lactoperoxidase-catalyzed iodination of T. pallidum and T. pertenue suggested differences in their surface proteins.

Original languageEnglish (US)
Pages (from-to)623-627
Number of pages5
JournalInfection and immunity
Volume42
Issue number2
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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