Comparison of lipid and non-lipid markers of atherosclerosis in arterial versus venous blood

Bruce Palmer, Linley E. Watson, Mark W. Riggs, Mark Lawrence, Clinton E. Baisden, Catherine J. McNeal, Ronald D. Macfarlane

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: Early studies have suggested that there may be differences in the concentration of lipoprotein particles and their associated apolipoproteins in arterial and venous blood and that this gradient might explain a proclivity to develop atherosclerotic lesions. The aim of this study was to use current methods of analysis to determine levels of these components, including particle densities and several common inflammatory markers in arterial and venous blood. Methods: Samples of arterial and venous blood were obtained nearly simultaneously in 26 patients undergoing right and left heart catheterization. Analyses were performed using enzymatic, immunoturbidimetric and ultracentrifugation assays. Results: Data obtained for total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, HDL and LDL particle density, high sensitivity C-reactive protein, serum amyloid-A and apoprotein B-100 concentrations in arterial and venous blood did not demonstrate any significant difference in the means. Conclusion: Arterial and venous blood can be used interchangeably to study the effect of blood concentrations of common soluble surrogate markers of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)286-288
Number of pages3
JournalAnnals of Clinical Biochemistry
Volume40
Issue number3
DOIs
StatePublished - May 2003

ASJC Scopus subject areas

  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Comparison of lipid and non-lipid markers of atherosclerosis in arterial versus venous blood'. Together they form a unique fingerprint.

Cite this